Project Grant R01MH143989
- The National Institute of Mental Health awarded New York University $837,599 on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate amygdala circuitry and fearful temperament in infants as a risk pathway for anxiety and related mental health challenges. The research identifies amygdala connectivity patterns associated with fearful temperament across the first two years of life, characterizes longitudinal changes in amygdala connectivity, and examines how...
- The National Institute of Mental Health awarded The Washington University $103,310 on August 3, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH144521) to investigate the causal dynamics of human amygdala-prefrontal circuits during fear extinction learning. The recipient will conduct intracranial electrophysiology and neuromodulation research using clinically indicated stereoelectroencephalography electrodes implanted in epilepsy patients undergoing SEEG monitoring....
- The National Institute of Mental Health awarded the University of Pittsburgh $705,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate spatially-organized prefrontal circuits regulating fear expression and discrimination. The research examines how the rostral and caudal prelimbic cortex of the mouse brain differentially regulate fear responses to threats versus non-threats. The work addresses the pathogenesis of anxiety and trauma-related...
- The National Institute of Mental Health awarded the University of Texas at Austin $439,250 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the causal role of the amygdala in emotional memory processes using transcranial focused ultrasound neuromodulation. The research tests whether direct modulation of amygdala activity with low-intensity transcranial focused ultrasound affects explicit memory processes in healthy adult volunteers, employing a...
- The National Institute of Mental Health awarded Emory University $628,380 on May 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate dopaminergic and noradrenergic mechanisms of emotion-related memory across development from childhood to adulthood. The research uses behavioral, psychophysiological, neuroimaging, and computational approaches across three aims. Aim 1 examines how affect induced by outcomes in a probabilistic reinforcement learning task influences...
- The National Institute of Mental Health awarded Rosalind Franklin University of Medicine & Science $465,301 on July 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how social deprivation during adolescence impairs basomedial amygdala development and compromises social behavior. The research examines the role of the basomedial amygdala in regulating social engagement across developmental stages, with specific focus on how atypical social...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $433,125 Project Grant to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) for a two-year project period from September 18, 2025 to September 17, 2027. This research initiative investigates the asymmetrical development of early B cell factor gene 1 (EBF1)-positive cells in the central amygdala and their functional consequences in emotion regulation and...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $127,224 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate neural mechanisms governing sensory-driven decision making through study of amygdala-striatal pathways. The K99 award (K99MH141244) funds research into how basolateral amygdala neurons projecting to the tail of the striatum instruct the selection of instrumental actions during perceptual decision making. The...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $426,250 in funding to Trustees of Boston College to support research on the neural circuit basis of safety learning. The research aims to investigate how interconnected brain regions like the basolateral amygdala, insular cortex, and infralimbic prefrontal cortex work together to process safety signals and mediate safety learning and...
- The National Institute of Mental Health awarded The Trustees of Princeton University $152,600 under the Mental Health Research Grants program (CFDA 93.242) on November 1, 2026, to conduct neural decoding research on biases in latent cause inference during fear extinction in anxiety disorders. The research leverages computational frameworks and neural decoding from optically-pumped magnetoencephalography (OPM-MEG) in combination with physiological markers including skin conductance response and...
The National Institute of Mental Health awarded the Trustees of Indiana University $436,006 on September 1, 2026, to investigate circuit operation underlying fear memory processes in the amygdala under the Mental Health Research Grants program (CFDA 93.242). The award funds research into the neural mechanisms regulating defensive behaviors and fear memory formation in the amygdala. Current models posit that the lateral amygdala serves as the primary input site for sensory information during fear learning and the principal locus of synaptic plasticity supporting fear acquisition. This project challenges that view through detailed examination of neural responses during Pavlovian fear conditioning at high temporal resolution. Preliminary findings indicate that lateral amygdala neurons exhibit habituation to repeated conditioned stimuli, with renewed conditioned stimulus-evoked spiking upon introduction of the unconditioned stimulus, concurrent with decreased unconditioned stimulus-driven responses. This inverse relationship appears to reflect the cellular mechanism by which neutral stimuli acquire emotional significance. The research also explores whether amygdala nuclei receive unconditioned stimulus-related input in parallel rather than sequentially, and uses projection-specific silencing of neural function to test functional hypotheses. Work is performed in Bloomington, Indiana, with a period of performance extending from September 1, 2026, through June 30, 2031. The award is classified as a Project Grant, the standard assistance type for NIMH research support up to five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $436.0k | 9/1/26 |