Project Grant K99MH144521
- The National Institute of Mental Health awarded The Washington University $735,920 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms of threat learning and avoidance behaviors. The research elucidates the temporal dynamics and causal roles of neurons in the supramammillary nucleus during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays. The project determines whether these...
- The National Institute of Mental Health awarded The Washington University $799,127 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop spectrally compatible optical sensors and actuators for in vivo real-time recording and perturbation of protein kinase A (PKA) activity. The project addresses gaps in understanding PKA spatiotemporal dynamics in living systems by creating molecular tools capable of simultaneous high-precision monitoring and...
- The National Institute of Mental Health awarded The Trustees of Princeton University $152,600 under the Mental Health Research Grants program (CFDA 93.242) on November 1, 2026, to conduct neural decoding research on biases in latent cause inference during fear extinction in anxiety disorders. The research leverages computational frameworks and neural decoding from optically-pumped magnetoencephalography (OPM-MEG) in combination with physiological markers including skin conductance response and...
- The National Institute of Mental Health awarded The Washington University $197,600 on September 28, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the cognitive and neurobiological underpinnings of reduced motivation and pleasure symptoms in psychotic and mood disorders with psychosis. The project integrates ecological momentary assessment, repeatable mobile cognitive testing, naturalistic fMRI stimuli, and individual-specific functional connectivity...
- The National Institute of Mental Health awarded the Trustees of Indiana University $436,006 on September 1, 2026, to investigate circuit operation underlying fear memory processes in the amygdala under the Mental Health Research Grants program (CFDA 93.242). The award funds research into the neural mechanisms regulating defensive behaviors and fear memory formation in the amygdala. Current models posit that the lateral amygdala serves as the primary input site for sensory information during fear...
- The National Institute of Mental Health awarded Lieber Institute Inc. $114,200 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support translational research on stress susceptibility in amygdala-prefrontal circuits underlying post-traumatic stress disorder (PTSD). The research investigates how traumatic stress impairs cellular and molecular function in neural circuits critical to fear regulation and extinction learning, with the objective of identifying...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $127,224 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate neural mechanisms governing sensory-driven decision making through study of amygdala-striatal pathways. The K99 award (K99MH141244) funds research into how basolateral amygdala neurons projecting to the tail of the striatum instruct the selection of instrumental actions during perceptual decision making. The...
- The National Institute of Mental Health awarded the University of Pittsburgh $705,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate spatially-organized prefrontal circuits regulating fear expression and discrimination. The research examines how the rostral and caudal prelimbic cortex of the mouse brain differentially regulate fear responses to threats versus non-threats. The work addresses the pathogenesis of anxiety and trauma-related...
- The National Institute of Mental Health, part of the Department of Health and Human Services, awarded the University of California, San Diego $684,740 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive mechanisms underlying fear extinction learning and to test whether computer-based working memory training enhances exposure-based treatment for anxiety disorders. The research will examine whether working memory training administered...
- The National Institute of Mental Health awarded The Washington University $197,612 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating non-invasive cerebellar stimulation and predictive coding in schizophrenia. The project addresses neurobiological mechanisms underlying delusions in schizophrenia by testing whether cerebellar dysfunction contributes to predictive coding deficits—errors in the brain's ability to update internal...
The National Institute of Mental Health awarded The Washington University $103,310 on August 3, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH144521) to investigate the causal dynamics of human amygdala-prefrontal circuits during fear extinction learning. The recipient will conduct intracranial electrophysiology and neuromodulation research using clinically indicated stereoelectroencephalography electrodes implanted in epilepsy patients undergoing SEEG monitoring. The project aims to determine nucleus-specific contributions of the amygdala and their interactions with the ventromedial prefrontal cortex and dorsal anterior cingulate cortex in human fear extinction and regulation. The work addresses a critical gap between animal models and human neurobiology in understanding fear processing mechanisms, with the long-term goal of developing targeted therapeutic interventions for fear-related disorders such as post-traumatic stress disorder. Performance occurs in St. Louis, Missouri, with a period of performance from August 3, 2026 through July 31, 2028. The K99 award supports a two-year postdoctoral research career development opportunity with no renewal option. The Washington University's Office of Sponsored Research Services serves as the recipient, administering the award through the institution's research enterprise.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $103.3k | 8/5/26 |