Project Grant R01MH143055
- The National Institute of Mental Health (NIMH) awarded a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Emory University to identify patients with true treatment failure for major depressive disorder (MDD) who may benefit from earlier referral to alternative treatments like transcranial magnetic stimulation, ketamine, and vagus nerve stimulation. The project aims to use trajectory classification methods to empirically separate partial response from true...
- The National Institute of Mental Health (NIMH) awarded a $1,199,261 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Ampa Inc. The grant, awarded on September 15, 2025, will fund the development of a next-generation Transcranial Magnetic Stimulation (TMS) system that aims to make highly effective, personalized depression treatment more accessible and scalable. The key innovations include precision TMS targeting using neurocardiac response signals, camera-based...
- The National Institute of Mental Health (NIMH) awarded a $1,688,034 Cooperative Agreement under the Mental Health Research Grants program (CFDA 93.242) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) to develop dynamic decision support tools for precision treatment of treatment-resistant depression (TRD). The project aims to: Create a pipeline to identify dynamic treatment regimes for TRD using electronic health, patient-reported, and digital biomarker data...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- The National Institute of Mental Health (NIMH) awarded a $514,178 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Laureate Institute For Brain Research, LLC in Oklahoma City, Oklahoma. The grant will support research to better understand the mechanistic relationship between brain circuit function and abnormalities in negative valence system behaviors, such as anhedonia and rumination, that contribute to treatment-resistant depression. The project will employ...
- This federal Cooperative Agreement award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,370,657 to The Washington University to develop and validate a clinical decision support tool called the Biotype-Assigned Augmentation Approach in Resistant Late-Life Depression (BAARD). The key objectives are to leverage existing data from ~700 older adults with treatment-resistant late-life depression (TRLLD) to: 1) develop and...
- This Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to establish reliable markers of prefrontal excitability that can be used to optimize repetitive transcranial magnetic stimulation (rTMS) treatment for depression. The $784,096 award, with a project period from May 1, 2025 to February 28, 2030, will allow researchers at The Leland Stanford Junior University to: 1) investigate how...
- This $769,753 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to leverage large-scale multimodal neuroimaging datasets to identify neural biomarkers and biotypes underlying post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders (ANXs). The research project, with an award period from Jul 21, 2025 to Apr 30, 2030, will utilize explainable deep learning...
- This federal Project Grant award of $392,500, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to characterize the role of sleep brain dynamics in the emergence of depression among adolescents. The primary awardee, the Research Institute at Nationwide Children's Hospital, will investigate how changes in sleep brain oscillations, such as increased frontal slow wave activity and reduced frontal sleep...
- This federal Project Grant award, titled "MAINTENANCE RTMS FOR DEPRESSION (MAITR-DE)", is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $968,769 award will support a multi-site study to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) in sustaining treatment response for individuals with treatment-resistant depression. The study will be conducted by the University of...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to develop personalized medicine strategies for tailored drug dose titration to modify brain electrophysiology during antidepressant therapy for treatment-resistant depression (TRD). The $284,333 award to The Washington University in Missouri will support research to enable dosing based on patient demographics and data-driven inferences of individual brain dynamics and neural circuitry, particularly targeting slow oscillatory activity and slow waves that can be elicited by anesthetic drugs. The project will run from August 2025 through June 2029, with the goal of advancing scientific understanding and innovative treatments for this debilitating mental health condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $284.3k | 8/4/25 |