Project Grant R01MH142640
- The National Institute of Mental Health awarded the University of Texas at Austin $3,093,180 on July 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) to investigate synaptic plasticity mechanisms that protect and refine local circuits in the brain. The research focuses on how synapse structure supports learning and memory, with specific emphasis on dendritic spines—small protrusions hosting most excitatory synapses in the brain. The project employs three-dimensional...
- The National Institute of Neurological Disorders and Stroke awarded The University of Texas Southwestern Medical Center $464,188 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of neurotransmitter release regulation by the protein munc13-1. The research examines how munc13-1 orchestrates assembly of SNARE protein complexes that fuse synaptic vesicle and plasma membranes, enabling...
- The National Institute of Mental Health awarded The University of Texas Southwestern Medical Center $1,645,997 on September 22, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct positron emission tomography imaging research examining microglial proliferation and its relationship to executive function and cognitive control deficits in virally-suppressed people with HIV. The project, titled "Imaging Microglia in Virally-Suppressed HIV," uses [11C]DPA-713...
- The National Institute of Mental Health awarded the University of Texas at Austin $439,250 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the causal role of the amygdala in emotional memory processes using transcranial focused ultrasound neuromodulation. The research tests whether direct modulation of amygdala activity with low-intensity transcranial focused ultrasound affects explicit memory processes in healthy adult volunteers, employing a...
- The National Institute of Mental Health awarded the University of Texas Health Science Center at Houston $114,792 on December 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of prefrontal cortex circuits in risky decision-making. The project runs through December 22, 2027, with performance at Houston, Texas. The research identifies neural mechanisms controlling the balance between reward seeking and threat avoidance by examining...
- The National Institute of Mental Health awarded the University of Wyoming $397,375 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of medial prefrontal cortex long-range recurrent neural networks in behavioral initiation and inhibition. The project, R21MH141703, will employ four translational behavioral paradigms (head-fixed persistent licking and shock-escape tasks; freely moving Fed3-based reversal learning and stop-signal tasks) combined...
- The National Institute of Mental Health awarded New York University $226,404 on September 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct experimental research examining how memory replay supports continual learning in the brain. The research tests two hypotheses: that the brain forms representations segregating context- and task-specific information while abstracting shared structure across tasks, and that replay supports continual learning by orthogonalizing...
- The National Institute of Mental Health awarded the University of Texas at Dallas $828,822 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate biobehavioral mechanisms linking physical activity, sedentary behavior, self-regulation, and loss of control eating in children and adolescents. The research employs a multi-method biobehavioral approach integrating neuroimaging, accelerometry, neurocognitive assessments, and ecological momentary assessment...
- The National Institute of Mental Health awarded the University of Texas at Austin $629,098 under the Mental Health Research Grants program (CFDA 93.242) on June 1, 2026, to develop advanced optical and sono-chemogenetic systems for probing dopamine dynamics in the non-human primate brain. The recipient will establish and characterize the dLight sensor, a genetically encoded fluorescent dopamine indicator, in the macaque animal model to enable cell-type-specific recording of dopamine circuitry....
- The National Institute of Mental Health awarded Emory University $100,228 on December 30, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on integrated mechanisms for corticostriatal control of action. The award funds investigation of how the orbitofrontal cortex, premotor cortex, and dorsomedial striatum interact to coordinate exploration-exploitation decision-making—the balance between trying new strategies and leveraging proven approaches. The...
The National Institute of Mental Health awarded The University of Texas Southwestern Medical Center $793,864 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neuronal mechanisms of control learning using human single unit recording. The research examines how frontal and medial temporal brain regions coordinate to support cognitive control and how disruptions in this coordination contribute to psychiatric illnesses. UT Southwestern will conduct rare simultaneous recordings of single neuron activity, local field potentials, and intracranial EEG in the human medial frontal cortex, hippocampus, and ventromedial prefrontal cortex to study theta-frequency oscillatory coordination in control learning. The work builds on prior findings that single neurons in human medial frontal cortex signal self-generated internal feedback, a critical driver of control learning. The research will define how internal feedback generated by medial frontal cortex neurons is utilized by the hippocampus and ventromedial prefrontal cortex to drive control learning and establish the specific roles of these regions and their coordination in this process. Performance occurs in Dallas, Texas, with a period of performance from September 1, 2026, through August 31, 2031. This is a Project Grant, an assistance type supporting investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $793.9k | 8/28/26 |