Federal Grant Award Summary

The University of Texas at Austin received a $629,098 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective June 1, 2026 through February 28, 2031. The award supports the development and characterization of advanced optical and sono-chemogenetic systems for probing dopamine dynamics in the non-human primate brain, specifically utilizing the macaque animal model. The project delivers two primary technical products: (1) establishment and characterization of the dLight sensor, a genetically encoded fluorescent dopamine indicator for real-time visualization of dopamine activity in primate neural circuits, and (2) development of an innovative sono-chemogenetic approach that leverages ultrasound-programmable nanoparticles for non-invasive, spatially-targeted modulation of dopamine signaling. These tools address a critical methodological gap by extending cell-type-specific neural recording and manipulation capabilities from smaller animal models to larger primates, which serve as essential preclinical models for advancing understanding of dopamine-related neurological and neuropsychiatric conditions.

The deliverables generated through this research funding include validated methodologies, experimental datasets, and characterization protocols applicable to dopamine circuitry research in primate systems. These products support the broader NIMH mission of transforming understanding and treatment of mental illnesses through basic and clinical research by providing researchers with sophisticated new technologies for investigating dopamine's role in cognitive processes and disease states. The work facilitates advancement of neurotherapeutic development and establishes foundational tools for future translational research in primate neuroscience models.