Project Grant R01NS150707
- The National Institute of Neurological Disorders and Stroke awarded New York University $550,743 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the mechanisms of assembly of endocytic machinery at the periactive zone and its coupling to the presynaptic active zone. The research dissects how the large GTPase dynamin organizes both the active zone, where neurotransmitters are released from...
- The National Institute of Neurological Disorders and Stroke awarded The University of Texas Southwestern Medical Center $1.311 million on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on interspecies blastocyst complementation as a method to study forebrain development, evolution, and function. The recipient will develop and apply a CRISPR-based blastocyst complementation approach to generate...
- The National Institute of Neurological Disorders and Stroke awarded The University of Texas Southwestern Medical Center $635,505 on June 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate ion channel dysfunction in cerebellar Purkinje cells and its contribution to TSC-associated neuropsychiatric disorders. The research will delineate how alterations in ion channel properties drive Purkinje cell dysfunction and...
- The National Institute of Mental Health awarded The University of Texas Southwestern Medical Center $793,864 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neuronal mechanisms of control learning using human single unit recording. The research examines how frontal and medial temporal brain regions coordinate to support cognitive control and how disruptions in this coordination contribute to psychiatric illnesses. UT Southwestern will...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas at Austin $393,284 on June 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on synaptic structural plasticity and stroke rehabilitation. The project examines how the brain remodels neural circuitry following stroke, with focus on reactive synaptogenesis—the growth of new connections among surviving neurons near...
- The National Institute of Neurological Disorders and Stroke (NINDS), a component of the Department of Health and Human Services National Institutes of Health, awarded Baylor College of Medicine $124,106 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant K99NS146618). The award funds research into the mechanisms of neurological manifestations in myotonic dystrophy type 1 (DM1), a progressive neuromuscular...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas Health Science Center at Houston $429,000 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing R21NS142863). The award funds research into the role of skull bone marrow neutrophils in delayed neurological decline following aneurysmal subarachnoid hemorrhage. The project investigates why skull neutrophils respond...
- The National Institute of Mental Health awarded the University of Texas at Austin $3,093,180 on July 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) to investigate synaptic plasticity mechanisms that protect and refine local circuits in the brain. The research focuses on how synapse structure supports learning and memory, with specific emphasis on dendritic spines—small protrusions hosting most excitatory synapses in the brain. The project employs three-dimensional...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
- The National Institute of Neurological Disorders and Stroke awarded Texas A&M University $500,307 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cross-neuronal structural plasticity in Drosophila motor circuits. The research addresses how different neuron and synapse types undergo structural rewiring in response to neural injury, with focus on how premotor neurons, motor neurons, and muscles in...
The National Institute of Neurological Disorders and Stroke awarded The University of Texas Southwestern Medical Center $464,188 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of neurotransmitter release regulation by the protein munc13-1. The research examines how munc13-1 orchestrates assembly of SNARE protein complexes that fuse synaptic vesicle and plasma membranes, enabling neurotransmitter release from neurons. The project specifically addresses the mechanisms by which munc13-1 opens a self-inhibited conformation of syntaxin-1 and how munc13-1 controls multiple forms of presynaptic plasticity dependent on calcium, diacylglycerol, and interacting proteins including calmodulin, doc2, and rim. Understanding these mechanisms is intended to inform development of therapies for neurological disorders including schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease, as well as other conditions that rely on similar exocytosis machinery such as secretion in neuroendocrine cells, B cells, and immunological synapses. Work is performed in Dallas, Texas. The performance period runs through May 31, 2031. This is a Project Grant, an assistance type providing support for discrete projects of specified duration.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $464.2k | 9/2/26 |