Project Grant R01MH142292
- This $246,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at The University of Texas Southwestern Medical Center (UT Southwestern) to investigate age-dependent dysfunction in the dentate gyrus (DG) region of the hippocampus and its relationship to the pathophysiology of psychosis. The research aims to reverse-translate discoveries from post-mortem human brain analyses, specifically...
- The National Institute of Mental Health (NIMH) awarded a $223,176 project grant under the Mental Health Research Grants program (CFDA 93.242) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The goal of this 2.5-year project is to define how novel post-translational modifications on histones, specifically histone crotonylation, are regulated by neuronal activity and to test their role in learning and memory. The...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of chromatin regulation in neuronal activity-induced gene expression and epigenetic memory. The $578,632 grant, awarded on March 1, 2025 to the University of Texas Southwestern Medical Center, aims to study how chromatin remodeling...
- The National Institute of Mental Health (NIMH) awarded a $439,804 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Creighton University. The grant supports a 5-year research project (11/15/2024 - 10/31/2029) to investigate the role of the lysine methyltransferase 5B (KMT5B) gene in regulating the expression of insulin-like growth factors (IGF1 and IGF2) and their impact on brain development and autism spectrum disorder. The research aims to specify KMT5B's role in...
- The National Institute of Mental Health (NIMH) awarded a $821,998 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Texas at Dallas (UTD). The grant, awarded on April 15, 2025, supports a 5-year research project to enhance non-viral, neuron-specific molecular delivery across species in the central nervous system (CNS). The project aims to characterize the capabilities of a novel 15-amino-acid peptide, N1, in selectively targeting neurons and...
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize a genetic mouse model for a gene implicated in neurodevelopmental disorders including autism, intellectual disability, and schizophrenia. The $742,484 award, with a project period from January 13, 2025 to October 31, 2029, will fund experiments to obtain multiome single nucleus RNA-sequencing,...
- This $328,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the phosphorylation-mediated regulation of the activity-regulated cytoskeletal-associated protein (ARC) and its interactions with the AMPA receptor endocytic machinery. The research, conducted by the University of Texas Southwestern Medical Center, aims to investigate the mechanism and regulation of ARC function in AMPA...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $237,750 to the University of California, Merced to study the role of the BAF chromatin remodeling complex in experience-induced neuronal gene transcription and synapse maturation, with implications for autism spectrum disorders (ASD). The 2-year project aims to elucidate the functions of the SMARCC2 subunit of the BAF complex in regulating...
- This Project Grant award of $241,380 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to advance the understanding of neurodevelopmental disorders (NDDs) and develop innovative therapies. The research program, led by researchers at Boston Children's Hospital, will use single-cell epigenomic technologies to link pathogenic variants in chromatin regulators, such as...
- The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $609,386 to The University of Texas Southwestern Medical Center (UT Southwestern) to elucidate the role of DNMT3A phosphorylation in regulating DNA methylation and its impact on neural gene expression and animal behavior. The 5-year project aims to: 1) determine how DNMT3A phosphorylation affects its methyltransferase function, 2) define the role of DNMT3A-mediated methylation in neural gene regulation, and 3) examine how neuronal activity influences DNMT3A phosphorylation and DNA methylation. This research could lead to new therapeutic strategies for neurological disorders such as autism spectrum disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $609.4k | 8/26/25 |