Project Grant K01NS142019
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $221,400 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Children's Hospital of Philadelphia (CHOP). This 5-year grant, beginning on August 1, 2025, aims to investigate the role of the c-Jun N-terminal kinase (JNK) signaling pathway in neurodevelopmental disorders (NDDs) such as autism and intellectual disability. The project will utilize...
- This $539,999 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of the NKX2.1 homeobox transcription factor in nervous system development. The research, to be conducted by Kennesaw State University, will utilize the nematode Caenorhabditis elegans as a model organism to better understand how NKX2.1 and related...
- This federal Project Grant award of $1,227,028 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the role of neuronal activity-induced transcription factors in neurodevelopment and neural plasticity. The award to President and Fellows of Harvard College, doing business as Harvard Medical School, funds investigations into how sensory-driven...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop novel small molecule inhibitors targeting the MBD2 protein for epigenetic therapy of medulloblastoma (MB), a common and aggressive pediatric brain cancer. The $564,045 award supports medicinal chemistry optimization of a lead compound, KCC07, which has shown promise in...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $230,904 to Boston Children's Hospital from January 1, 2025 to December 31, 2029. The award will support research to identify novel genetic causes of infantile epilepsies and evaluate the impact of genetic diagnosis on patient outcomes and families. Key objectives include applying...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $127,145 to The Trustees of Princeton University to conduct research dedicated to unraveling the regulatory mechanisms governing chromatin organization and gene transcription during neural development in the Drosophila model organism. The primary focus is on understanding how...
- Northwestern University received a $420,790 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 15, 2023. The funding will support a research project titled "Deep Mutational Scanning of CHD2 for Variant Interpretation in Neurodevelopmental Disorders". This effort aims to develop a high-throughput assay to evaluate the functional...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $160,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate the epigenetic mechanisms underlying neurodevelopmental defects in Menke-Hennekam Syndrome, a rare genetic disorder caused by mutations in the EP300 gene. The project aims to (1) identify maturation and...
- This federal Project Grant award of $264,600.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate the mechanisms of HP1B-mediated heterochromatin regulation and the impact of patient-identified CBX1 variants in mouse models of CBX1-related syndrome. The research aims to investigate the role of HP1B, a core structural protein...
- This federal Project Grant award in the amount of $426,650 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research by Trustees of Tufts College, doing business as Tufts University, to develop a hybrid strategy for efficiently deriving region-specific neural cell populations, including oligodendrocytes and neural crest progenitors,...
This Project Grant award of $241,380 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to advance the understanding of neurodevelopmental disorders (NDDs) and develop innovative therapies. The research program, led by researchers at Boston Children's Hospital, will use single-cell epigenomic technologies to link pathogenic variants in chromatin regulators, such as KMT2D, to specific neuronal phenotypes in NDD models. The goal is to provide insights into the molecular mechanisms underlying these prevalent but poorly understood disorders, which impair language, learning, motor skills, and neurological function. The award will fund a 5-year research and training program to equip the principal investigator with the skills to become an independent investigator in this field.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $241.4k | 8/6/25 |