Project Grant R01MH141942
- The National Institute of Mental Health awarded a cooperative agreement totaling $2,039,804 to Oregon Health & Science University on March 2, 2026, to optimize cAMP and PKA sensors for cell-specific dissection of neuronal circuits in vivo under the Mental Health Research Grants program (CFDA 93.242). The recipient will develop fluorescence-based biosensors that enable real-time visualization of neuromodulatory signaling within specific cell types during animal behavior. The work involves...
- The National Institute of Mental Health awarded the University of Washington a cooperative agreement totaling $2,305,031 on March 9, 2026, to engineer red fluorescent calcium and neuromodulator sensors for multiplexed neuronal imaging. This work is funded under the Mental Health Research Grants program (CFDA 93.242). The project leverages the Opto-Mass sensor screening platform and machine learning models to accelerate fluorescent sensor development, addressing limitations in dynamic range,...
- The National Institute of Mental Health awarded The Washington University $735,920 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms of threat learning and avoidance behaviors. The research elucidates the temporal dynamics and causal roles of neurons in the supramammillary nucleus during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays. The project determines whether these...
- The National Institute of Mental Health awarded The Washington University $140,109 on June 1, 2026, to develop, disseminate, and sustain cloud-based software tools for optical brain mapping under the Mental Health Research Grants program (CFDA 93.242). The award funds sustainable development, dissemination, and training for scalable software resources that standardize processing workflows in optical neuroimaging, specifically functional near infrared spectroscopy (fNIRS) and high-density diffuse...
- The National Institute of Mental Health awarded The Washington University $103,310 on August 3, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH144521) to investigate the causal dynamics of human amygdala-prefrontal circuits during fear extinction learning. The recipient will conduct intracranial electrophysiology and neuromodulation research using clinically indicated stereoelectroencephalography electrodes implanted in epilepsy patients undergoing SEEG monitoring....
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $2,565,783 to Oregon Health & Science University (OHSU) from September 1, 2023 to August 31, 2026 to develop novel genetically encoded sensors and actuators for monitoring and manipulating neuromodulatory signaling activities in the brain at the cellular and circuit levels. The project aims to enable large-scale in vivo...
- The National Institute of Mental Health awarded The Washington University $763,894 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ZNF292 gene in cortical development and neurodevelopmental disorders. The research employs complementary experimental systems—mouse knockout models and human pluripotent stem cell-derived neurons carrying six pathogenic ZNF292 variants identified in patients with autism spectrum disorder, intellectual...
- The National Institute of Mental Health awarded The Washington University $197,600 on September 28, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the cognitive and neurobiological underpinnings of reduced motivation and pleasure symptoms in psychotic and mood disorders with psychosis. The project integrates ecological momentary assessment, repeatable mobile cognitive testing, naturalistic fMRI stimuli, and individual-specific functional connectivity...
- The National Institute of Mental Health awarded The Rockefeller University $1,443,030 on September 20, 2025, under Mental Health Research Grants (CFDA 93.242) to develop an optimized two-photon optical imaging system for high-fidelity population voltage imaging in intact neural tissue using genetically encoded voltage indicators (GEVIs). The recipient will design and implement a two-photon multiplexing platform adapted to the unique requirements of GEVIs, incorporating a novel spike detection...
- Federal Grant Award Summary The University of Washington received a $461,714 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025, through August 31, 2027. This award supports the development of genetically encoded fluorescent biosensors capable of real-time monitoring of sex steroid hormones—specifically estrogens and androgens—within the brain. The primary deliverables include engineering...
The National Institute of Mental Health awarded The Washington University $799,127 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop spectrally compatible optical sensors and actuators for in vivo real-time recording and perturbation of protein kinase A (PKA) activity. The project addresses gaps in understanding PKA spatiotemporal dynamics in living systems by creating molecular tools capable of simultaneous high-precision monitoring and manipulation of PKA activity. Specific deliverables include functional photoactivatable PKA inhibitors (PA-PKI) and red and far-red PKA activity sensors designed for multiplexed imaging compatible with existing green biosensors. The work will enable concurrent in vivo perturbation and evaluation of perturbation efficacy to assess physiological outcomes across cellular signaling networks and animal behavior. The award supports research at Washington University's Office of Sponsored Research Services in St. Louis, Missouri, from September 1, 2026, through June 30, 2031. This is a Project Grant, the standard NIH research assistance type supporting defined projects typically funded for up to five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $799.1k | 9/1/26 |