Project Grant R01MH139547
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is focused on developing novel tools to enable researchers to better understand how brain structure relates to brain function. The $323,978 award to the Child Mind Institute Inc. will fund three main efforts: Extending the institute's "BrainBuilder" tool to reconstruct 3D mesoscale microstructural atlases of the human and macaque cortex, including...
- This federal Project Grant award of $702,928 was provided by the National Institute of Mental Health (NIMH), which administers the Mental Health Research Grants program (CFDA 93.242), to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant supports research to enhance the integration of multi-organ imaging data of the brain and body, psychiatric genetic studies, and functional genomic data resources to uncover...
- This $1,988,947 Project Grant award from the National Institute of Mental Health (NIMH), under the Federal Grant Program "Mental Health Research Grants" (CFDA 93.242), will fund the development of a scalable high-throughput proteomics profiling pipeline to generate comprehensive molecular atlases of distinct brain cell types in the mouse brain. The key products and services to be delivered include: Increasing the multiplexing capability to 100-plex for antibody-based proteomic...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
- This federal Project Grant award of $417,200.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize and manipulate large-scale brain activity patterns associated with attention, focus, and psychiatric/neurological disorders. The project aims to 1) determine whether patterns of quasi-periodic brain activity observed in functional MRI data reflect underlying neural activity patterns...
- This $769,753 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to leverage large-scale multimodal neuroimaging datasets to identify neural biomarkers and biotypes underlying post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders (ANXs). The research project, with an award period from Jul 21, 2025 to Apr 30, 2030, will utilize explainable deep learning...
- This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,093,825 to implement the PSYCH-DS data standard for human behavioral experiments. The key objectives are: 1) Creating validator software to ensure cross-compatibility of PSYCH-DS datasets across programming languages, 2) Integrating the PSYCH-DS standard into three popular experiment presentation software packages, and 3) Developing...
- This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
- The National Institute of Mental Health (NIMH) awarded a $744,121 project grant under the Mental Health Research Grants program (CFDA 93.242) to The Leland Stanford Junior University. The grant aims to develop foundation models (FMs) - a novel artificial intelligence approach - to analyze large brain imaging datasets and address challenges in clinical neuroscience and psychiatry research. Key objectives include creating FMs tailored for open-source functional MRI datasets, integrating...
This federal Project Grant award of $536,418 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will enhance the capabilities of the open-source analysis tool PALM (Permutation Analysis of Linear Models). The primary goals of this 3-year project (9/1/2025 - 8/31/2028) are to: 1) Develop and implement approaches for analyzing repeated measures (longitudinal) and genetic (familial) data using permutation tests, with a focus on large-scale brain imaging datasets from initiatives like the Adolescent Brain Cognitive Development Study and Human Connectome Project; 2) Develop and implement novel statistical test methods that are sensitive to spatial and temporal processes across the brain, even for data measured in different domains, scales, and representations; and 3) Expand PALM's functionality to enable efficient, rigorous analyses of the unprecedented size and detail of modern neuroscience datasets. This project will enhance researchers' ability to integrate and analyze complex neuroscience data using optimal, minimally-assuming statistical methods.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $536.4k | 8/28/25 |