The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 Mental Health Research Grants) to the Scripps Research Institute to conduct research on the genetic basis of autism spectrum disorder and neurodevelopmental delay. The project, titled "Scalable Functional Analysis of Neuropsychiatric Risk Genes with Spatially Integrated In Vivo Perturb-Seq," aims to use advanced in vivo genetic screening and whole-brain imaging techniques to investigate how...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a study investigating the cognitive and psychopathological profiles of individuals with autism spectrum disorder (ASD) who carry genetic variants associated with both ASD and schizophrenia (SCZ). The $388,800 award to The Trustees of Columbia University will remotely assess cognition and psychopathology in 400 ASD participants, half of whom carry the...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $251,250 to support research on sex-dependent dysregulation of parvalbumin interneurons as a pathway to autism spectrum disorder (ASD). The research aims to study whether in utero exposure to anti-CASPR2 antibodies has sex-specific epigenetic effects on the maturation of parvalbumin interneurons, which may contribute to network imbalance in male mice....
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research into the neural substrates of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). The $367,708 award to the University of Southern California will use cutting-edge neuroimaging and advanced statistical modeling to investigate functional connectivity patterns in the brain's reward circuitry and how they...
The University of California, Los Angeles (UCLA) was awarded a $165,796 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant, titled "Functional Genomic Interrogation of Autism Spectrum Disorder Genetic Risk on Microglia-Neuronal Interactions", will support research to assess the impact of autism spectrum disorder (ASD) genetic risk on microglial function and neuronal-microglial interactions using human...
This Project Grant award of $253,500.00 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to resolve the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal structure and function. The key products or services to be delivered through this award include: 1) establishing...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the contribution of noncoding tandem repeat expansions in the etiology of autism spectrum disorder (ASD). The $188,393 award, with a performance period of August 15, 2024 to June 30, 2028, will be used by the University of Nevada, Las Vegas (UNLV) to: 1) identify high-confidence...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $837,131 to Yale University to conduct research aimed at improving the inclusion of individuals with intellectual disability in autism neuroscience studies. The project will apply innovative technological and clinical approaches to collect neural and visual attention data, using electroencephalography (EEG) and eye-tracking, from 70...
The federal Project Grant award K08MH139983, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to determine the information processing changes underlying the phenotype of an autism spectrum disorder (ASD) risk gene in rats. The $196,597 award, with a project period from July 1, 2025 to June 30, 2029, will enable the awardee, The Regents of the University of California, San Francisco, to employ automated...
This $439,804 Project Grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research by Creighton University to investigate the role of the KMT5B gene in regulating the expression of insulin-like growth factors (IGF1 and IGF2) and their impact on neurodevelopmental phenotypes associated with autism spectrum disorder. The research objectives are to: 1) specify the role of KMT5B in regulating paracrine (local brain)...