This federal Project Grant award of $418,750 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to mechanistically uncover the neuroanatomical substrates of anxiety-related brain circuits in humans. The research team at Yale University will use invasive neurophysiology and direct electrical brain stimulation to study the individual and complementary roles of the dorsal anterior cingulate cortex and anterior insula...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a research project to elucidate the neural mechanisms governing fear and anxiety responses within the hippocampal-amygdala circuit in humans. The $211,248 award, spanning from March 1, 2025 to February 28, 2030, aims to: 1) investigate the acquisition, extinction, and renewal of fear responses using a virtual reality experiment; 2)...
This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), aims to characterize the role of the human superior colliculus in defensive behavior, emotional arousal, and the pathophysiology of anxiety disorders. The $1,940,236 award to Emory University will support a 5-year research project that uses functional MRI, computational neuroimaging, and data from the Adolescent Brain Cognitive Development Study...
The National Institute on Aging (NIA) awarded a $2,044,038 Project Grant (CFDA 93.866 - Aging Research) to New York University (NYU) School of Medicine, with a performance period from September 1, 2024 to August 31, 2027. The grant will fund research to investigate the mechanism of anxiety in Alzheimer's disease, focusing on the hyperactivity of the thalamo-hippocampal-prefrontal circuit. The project aims to elucidate the functional synaptic architecture of this neural circuit, determine its...
This $112,158 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to identify basal ganglia neural activity associated with depression in Parkinson's disease (PD) patients. The primary objectives are to: 1) use machine learning techniques to characterize basal ganglia neural activity differences between PD...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $885,500 to the University of California, Davis to conduct research on the neural circuits that modulate social behavior and anxiety. The research team will use the Fast Light and Calcium-Regulated Expression (FLICRE) system to tag and genetically define the specific cell types in the extended amygdala and nucleus accumbens that are active during...
This $173,140 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of California, San Francisco (UCSF) to elucidate the role of neural activity in the degeneration of midbrain dopamine neurons associated with Parkinson's disease. The project aims to utilize novel mouse models to chronically manipulate the...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will provide $390,000.00 in funding to the University of Texas Health Science Center at Houston from April 15, 2025 to February 28, 2030. The research project aims to examine how the hypothalamic prodynorphin (PDYN) neurocircuits regulate flexible defensive behaviors, such as flight and freezing responses, that are impaired in anxiety disorders like...
This Project Grant award from the National Institute of Mental Health (NIMH), under the CFDA 93.242 Mental Health Research Grants program, is funding a $196,460 research project at Emory University to investigate the neural mechanisms underlying novelty-related social behaviors in mice. The project aims to use in vivo recording techniques, optogenetic stimulation, and computational approaches to elucidate how the ventral hippocampus, lateral septum, and nucleus accumbens pathway mediates the...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $781,464 to develop a "causal wiring diagram of transdiagnostic brain functions." The research aims to use brain stimulation technology and functional MRI to map causal brain circuitry associated with a range of mental health conditions, including major depression, obsessive-compulsive disorder, schizophrenia, and generalized...