Project Grant R21MH139213

Award Date 6/9/25
Completion Date 6/8/27
Dollars Obligated $458K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
The National Institute of Mental Health (NIMH) awarded a $392,500 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine to study the developmental origins of mental illness. The 5-year grant, which begins on January 1, 2025, will test the hypothesis that early life adversity impacts the structure and function of the hypothalamus, a brain region that integrates brain and bodily states, thereby contributing to maladaptive behaviors underlying mental...
This Project Grant award of $738,037 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to investigate the prevalence and predictors of attenuated psychotic symptoms (APS) among youth endorsing persistent distressing psychotic-like experiences. The key objectives are to: Examine the prevalence of APS among youth in the Adolescent Brain Cognitive Development (ABCD) study sample and compare rates to other forms of...
This $148,142 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a study examining the neurodevelopmental trajectories of the hippocampus and their role as a mechanistic explanation for adverse mental health outcomes following child maltreatment. The project will leverage data from the Adolescent Brain Cognitive Development (ABCD) Study to: 1) identify trajectories in adolescent hippocampal...
The National Institute of Mental Health (NIMH) awarded a $200,607 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of North Carolina at Chapel Hill (UNC-CH). The grant funds a 2-year research study examining patterns of neurobiological, behavioral, and psychological processes that define distinct subtypes of youth experiencing suicidal thoughts and behaviors (STBs) in late childhood and adolescence. The study aims to leverage the Adolescent Brain...
This federal Project Grant award for $818,253 from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants supports a 5-year longitudinal study by the University of California, San Francisco (UCSF) to evaluate the association between abnormalities in the neuromodulatory system and symptoms of depression, cognition, and motor frailty in older adults with late-life depression. The study aims to demonstrate that structural and functional...
The National Institute of Mental Health (NIMH) awarded a $509,310.95 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Texas at Austin to investigate longitudinal trajectories and social mechanisms of depression in adolescent girls with autism spectrum disorder (ASD). The 3-year research project aims to: 1) map depression symptom trajectories in adolescent girls with ASD compared to typical development, 2) profile daily social experiences relevant to negative...
This $2,567,596 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a longitudinal study on the impacts of adverse childhood experiences (ACEs) on the sexual, reproductive, and mental health outcomes of young adults in Malawi, as well as the intergenerational transmission of ACEs. The key products and services to be delivered through this 5-year project...
This federal Project Grant award, valued at $175,647.00 and awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the relationship between positive childhood experiences, prenatal biobehavioral resilience, and postpartum mental health and well-being. The key objectives of this 5-year project are to: 1) examine how positive childhood experiences are associated with physiological and self-reported...
This $792,441 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to investigate the dynamic trajectory of behavioral, physiological, and neurobiological stress responses in female adolescents at high and low familial risk for depression. The key objectives are to: 1) Track changes in default mode network (DMN) and central executive network (CEN) dynamic properties from before to after an acute psychosocial...
This $1,892,487 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support a short-term longitudinal experimental investigation into the effects of acute stress on memory performance between maltreated and non-maltreated adolescents aged 12-17. The study will be conducted by the University of California, Irvine and will involve randomly assigning participants...

The National Institute of Mental Health (NIMH) awarded a $458,177 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Regents of the University of California, San Francisco (UCSF) to conduct research leveraging population-level data to inform prevention and treatment of adolescent depression following adverse childhood experiences (ACEs).

The overarching goal of this 2-year research project is to gain robust insights into the heterogeneity of the association between ACEs and adolescent depression symptoms. The research team will use data from the Adolescent Brain and Cognitive Development (ABCD) study to model the effect of various sociodemographic, family, peer, and pubertal factors that may modify the relationship between ACEs and changes in depression symptoms from ages 9-10 to 14-15. The findings will help inform the development of more targeted, effective programs and policies focused on ACEs prevention and mental health treatment for adolescents.

Generated 7/1/25, 3:47 AM