This $148,423 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to clarify sensory feedback and brain mechanisms associated with motor control deficits in individuals with autism spectrum disorder (ASD), both with and without intellectual disability (ID). The five-year study, beginning on Sep 1, 2024, will examine sensorimotor physiology during fine (precision gripping) and gross (postural...
This $237,750 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support a research study conducted by the University of California, Merced. The study aims to elucidate the neurodevelopmental functions of the SMARCC2 gene and the Brahma Associated Factor (BAF) chromatin remodeling complex, which have been strongly implicated in autism spectrum disorders (ASD). Specifically, the research will investigate how...
This National Institute of Mental Health (NIMH) Project Grant under the Mental Health Research Grants program (CFDA 93.242) will provide $194,940 in funding from July 1, 2024 to June 30, 2028 to support a research program led by Dr. Mo at Boston Children's Hospital. The goal is to study the role of somatic (post-zygotic) genetic variants in the risk and mechanisms of autism spectrum disorder (ASD). The project will utilize a combination of whole exome sequencing, ATAC-seq, whole genome...
This $504,283 federal Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund a prospective cohort study examining the etiology of autism spectrum disorder (ASD) in children born preterm compared to term-born children. The study aims to: 1) Determine the epidemiology of ASD in preterm children and identify associated risk factors; 2) Estimate...
The National Institute of Mental Health (NIMH) awarded a $437,250 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh to study the role of local interneurons in early cortical dysfunction in Shank3 knockout mice, a model of autism spectrum disorder (ASD). The grant will fund research using whole-cell electrophysiology and 2-photon microscopy to characterize the physiological properties of Shank3 knockout cortical parvalbumin and somatostatin-positive...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, provides $367,708 to the University of Southern California (USC) to investigate the neural mechanisms underlying autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). The project will use advanced neuroimaging techniques and machine learning methods to analyze functional connectivity patterns of the brain's reward circuitry in...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to study caregiver perception of infant cries as an early marker for autism spectrum disorder (ASD). The $297,083 award to the University of Missouri System will: 1) Replicate and extend the association between caregiver cry perception and autism outcomes to identify the acoustic features driving perceptual differences, and 2)...
The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA to conduct scalable functional analysis of neuropsychiatric risk genes using spatially integrated in vivo perturb-seq technology. This 5-year research project aims to comprehensively map the functions of 72 high-confidence autism spectrum disorder and neurodevelopmental delay (ASD/NDD) risk genes in the neocortex and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $255,362 to Temple University to research the neural mechanisms underlying reward processing in autistic adolescents. The key objectives are to: 1) isolate differences in neural response to social and non-social rewards between neurotypical and autistic youth, 2) quantify differences in midbrain dopamine system function between the two groups via...
The National Institute of Mental Health (NIMH) awarded a $1,111,187 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Georgetown University. The grant, with a period of performance from July 15, 2024 to January 31, 2029, will support research to investigate how the chromatin remodeling protein CHD1 regulates synaptic homeostatic plasticity and its role in autism spectrum disorder (ASD) pathogenesis. The project aims to delineate the CHD1-dependent signaling network...