This Project Grant award of $237,000 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research by Northeastern University to investigate the role of the hormone allopregnanolone in producing long-term alterations in brain activity and behavior related to pregnancy and motherhood. The research aims to establish a causal, mechanistic link between the hormonal changes of pregnancy and the subsequent neural and...
This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...
This Project Grant award of $396,250 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at Vanderbilt University to investigate the regulation of metabotropic glutamate receptor (mGluR) activity by protein-protein interactions. The research aims to: 1) test a suite of agonists, positive allosteric modulators (PAMs), and negative allosteric modulators (NAMs) for activity at mGluR7 with and without the protein...
This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a multi-site study to examine the role of neuroactive steroids and GABA-A receptor plasticity in premenstrual dysphoric disorder (PMDD) and its treatment with low-dose selective serotonin reuptake inhibitors. The $486,416 award, effective September 11, 2024 through June 30, 2029, will assess plasma neuroactive steroid changes, GABA-A...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $659,217 to develop a novel microelectrode sensor to continuously measure endogenous neuropeptide Y (NPY) release in brain tissue and single cells. The primary objective is to enhance detection of NPY, a key neuropeptide implicated in neurological disorders, by optimizing an existing NPY biosensor to improve sensitivity and selectivity while...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding a $267,310 research project conducted by Trustees of Boston University, doing business as Boston University Medical Campus. The project aims to compare the spatial distribution, kinetics, and synaptic physiology of dendritic inhibition on pyramidal cells in the anterior cingulate cortex (ACC) and lateral prefrontal cortex (LPFC) of rhesus macaques....
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will provide $671,340 to the University of Alabama at Birmingham (UAB) over a 5-year period starting May 1, 2025. The objective of this research project is to investigate the cellular mechanisms within the amygdala that drive shifts in valence processing (the brain's perception of positive and negative stimuli) across the female reproductive cycle....
This $444,125 Project Grant, awarded on July 18, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The key objectives are to: 1) Use mouse models to assess how modulating progesterone receptor signaling affects migraine...
This Project Grant award of $535,153 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of molecular and cellular networks involved in mood regulation in major depressive disorder (MDD). The project aims to identify transcriptomic changes associated with MDD in a sample of 800 subjects across three key brain regions: the anterior cingulate cortex, basolateral amygdala, and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to investigate sex differences in the impact of prenatal stress on cognitive dysfunction and resilience to stress. The $711,361 award to Loyola University of Chicago, Health Sciences Campus will support a 5-year study to determine if RNA editing of the GluA2 subunit of the AMPA glutamate receptor mediates the long-term detrimental effects...