This $461,084 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research at Yale University to elucidate how neurons producing the neurotransmitter beta-endorphin (POMC neurons) respond to and regulate social behaviors during development. The research aims to map the in vivo responses of POMC neurons to social cues across different developmental stages (infant, juvenile, and adult mice) using...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $719,917 to investigate the effects of chronic stress on cognitive flexibility and the underlying cellular mechanisms in the prefrontal cortex. The key objectives are to: Examine sex-dependent effects of chronic stress on cognitive flexibility and related changes in synaptic regulation and activity of specific neuronal subpopulations in the...
The National Institute of Mental Health (NIMH) awarded a $245,475 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on defining the neuro-immune and placental profile of a dual-hit Toll-Like Receptor 7 (TLR7) and stressor mouse model. The key objectives of this 2-year research project are to determine whether prenatal TLR7 stimulation induces maternal, placental, and...
The National Institute of Mental Health (NIMH) awarded a $1,932,991 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Yale University to conduct research on neural computations underlying learning, decision-making, and memory. The 5-year project aims to characterize core computations of value, uncertainty, and prediction error across cognitive processes and domains, and identify associations between these computations and symptoms of anxiety and stress-related disorders. The...
This $444,125 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to investigate the role of serotonergic neurons in alterations to adult social behavior following early life adversity. The research team at George Washington University will use the limited bedding and nesting model of early life adversity in mice to study the links between early experience, the serotonergic system, and...
This $742,484 federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants will support research to characterize a genetic mouse model and delineate its function in the brain. The project aims to obtain multi-omic single-nucleus RNA sequencing and ATAC-seq data to analyze and correlate gene expression and chromatin modifications in the mouse brain at three critical developmental time points and two key brain regions....
This $148,142 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a study examining the neurodevelopmental trajectories of the hippocampus and their role as a mechanistic explanation for adverse mental health outcomes following child maltreatment. The project will leverage data from the Adolescent Brain Cognitive Development (ABCD) Study to: 1) identify trajectories in adolescent hippocampal...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) totaling $196,460.00 will support research to elucidate the neural mechanisms underlying social recognition and investigation behaviors in mice. The primary objective is to leverage advanced in vivo recording techniques, optogenetic stimulation, and computational approaches to determine how information about the novelty of a social stimulus is encoded...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $246,000.00 to The University of Texas Southwestern Medical Center to conduct research on understanding the relationship between age-dependent dysfunction in the dentate gyrus (DG) region of the hippocampus and the onset of psychosis. The research aims to reverse-translate findings from post-mortem human brain analyses to investigate how gradual...