This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), is funding a research project to investigate the circuit mechanisms underlying interactions between distinct learning systems. The $1,425,651 award, with a start date of July 18, 2024 and an ultimate completion date of March 31, 2029, is being provided to the University of Maryland, Baltimore to conduct this multi-level, interdisciplinary...
The federal Project Grant award R01MH139352, totaling $429,323.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The grant supports research to investigate cognitive flexibility and the neural mechanisms underlying cognitive thalamocortical dynamics, with the goal of advancing understanding and treatment of mental illnesses characterized by cognitive inflexibility, such as schizophrenia. The primary awardee is New...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $418,750 to Yale University to conduct research aimed at mechanistically uncovering the neuroanatomical substrates of anxiety-related brain circuits. The 5-year project, starting on February 1, 2025, will utilize invasive neurophysiology and direct electrical brain stimulation in epilepsy patients to delineate the individual and...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to determine how model-based decision-making is represented in distinct cell types within the prelimbic cortex and dorsomedial striatum, two brain regions implicated in compulsive disorders. The $189,540 award, which runs from February 1, 2025 to January 31, 2030, will fund in vivo electrophysiology and optogenetics...
This federal Project Grant award, identified as R01MH138895, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The primary goal of this $857,903 award, with a period of performance from April 17, 2025 to January 31, 2030, is to leverage computationally derived measures of individual differences in learning and decision-making to predict psychiatric diagnosis, symptoms, and changes in symptom severity over time. The award...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research aimed at understanding the neural substrates of context-dependent decision-making in mice. The $252,125 award, spanning September 2024 to March 2028, will leverage whole-brain functional magnetic resonance imaging (fMRI) and advanced optogenetic techniques to: 1) identify brain regions involved in the maintenance of contextual information,...
The National Institutes of Health National Institute of Mental Health awarded Yale University $7,389,444 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2022 for a project concluding on August 31, 2025. The award will support Yale University in conducting a multivariate investigation to identify latent factors linking internalizing disorders such as anxiety, major depressive disorder, and posttraumatic stress disorder with COVID-19 outcomes including infection,...
This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $797,157 to Yale University to conduct research aimed at understanding circuit dysfunction in individuals with neuropsychiatric manifestations of post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). The 5-year project, starting on December 1, 2024, will leverage Yale's Neurocovid Clinic and the COVID Mind Study to recruit...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is providing $107,948.00 to The Johns Hopkins University to study the computational mechanisms underlying single neuron activity within brain-wide circuits. The research aims to characterize the relationships between synaptic input patterns and action potential generation in cortical neurons, investigate how inputs change when the brain drives specific neuron...