This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a $424,875 research project titled "Adolescent Trauma Produces Enduring Disruptions in Sleep Architecture that Lead to Increased Risk for Adult Mental Illness." The project aims to: 1) determine if individual differences in sleep profiles following adolescent stress can predict adult behavioral outcomes related to depression and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,432,724 to Montana State University to conduct research on the developmental impacts of sleep patterns on positive valence systems and socioemotional functioning during pre-adolescence. The research project will utilize a longitudinal study design and an experimental protocol to examine the mechanistic pathways between behavioral and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $121,424 to the University of California, Los Angeles (UCLA) to conduct research on the relationship between early sleep disturbance and neurodevelopmental trajectories in infancy. The key activities involve longitudinally examining how specific sleep metrics, such as sleep latency and efficiency, relate to functional brain networks and later...
This federal Project Grant award, R01MH136491, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $588,018 award, effective from September 18, 2024 to July 31, 2029, supports research to investigate the neural basis underlying the impact of stress on sleep. The research aims to determine how stress-regulatory neurons in the locus coeruleus and paraventricular nucleus of the hypothalamus disrupt distinct features of...
This $195,000 Project Grant was awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to the Research Institute at Nationwide Children's Hospital (RINCH). The grant supports a 2-year research project titled "Characterizing the Role of Sleep Brain Dynamics in the Emergence of Depression in Adolescents." The project aims to (1) identify the space-time profiles of sleep slow oscillations and spindles, and contrast these...
This $162,486 federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA program 93.242 - Mental Health Research Grants supports a study on the role of sleep disturbances in the perimenstrual exacerbation of depression and suicidality. The study utilizes high-resolution digital health sleep data from a previous NIMH-funded clinical trial in 150 individuals assigned female at birth (AFAB) with suicidality. It aims to evaluate how sleep patterns and cycling hormones...
This federal Project Grant award of $665,893 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to study the role of hippocampal activity during sleep in stabilizing and isolating memories of experiences across different contexts. The research will utilize advanced machine learning techniques and large-scale population recordings to quantify the tuning and retuning of individual neurons and the interactions of...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $633,671 to Rutgers, The State University of New Jersey to conduct research on the safety of prescription sleep medications in children, adolescents, and young adults with Attention Deficit Hyperactivity Disorder (ADHD). The key objectives of this 5-year research project are to: 1) evaluate nationwide patterns of prescription sleep medication...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $809,312 to Duke University to characterize circadian function and sleep disturbances among 250 children with Attention-Deficit/Hyperactivity Disorder (ADHD). The study aims to: 1) Assess individual differences in circadian function and sleep profiles using laboratory-based dim light melatonin onset (DLMO) testing and wearable sensors; 2) Examine...
The National Center for Complementary and Integrative Health (NCCIH) has awarded a $425,847 project grant (CFDA 93.213) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, to conduct research on the mechanisms and consequences of infraslow oscillations in sleep. The research aims to: 1) identify how network interactions between the dorsomedial medulla and locus coeruleus regulate the infraslow power rhythm, using...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) totaling $4,698,676 will support a longitudinal study to investigate the developmental trajectories of sleep electroencephalogram (EEG) biomarkers and their association with psychopathology through young adulthood. The research will be conducted by Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center. The study aims to leverage sleep EEG data from a population-based child cohort to examine how the maturation of slow wave activity, sleep spindle density, and odds ratio product - biomarkers of sleep intensity, integrity, and depth - relate to the emergence of internalizing symptoms, suicidality, externalizing behaviors, and working memory deficits in young adults. The research will assess potential sex differences in these associations. The findings are intended to inform the development of novel biomarkers for clinical trials targeting the pathophysiology and prognosis of diverse mental health disorders across the lifespan by focusing on the sleeping brain.