Project Grant R01MH136197
- This Project Grant award of $777,016.00 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the synaptic mechanisms of continuous theta burst stimulation (CTBS) in the treatment of depression. The project aims to investigate whether CTBS reduces excitation via N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) and/or enhances inhibition via gamma-aminobutyric acid receptors (GABARs) in...
- This $514,178 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to investigate the relationship between brain circuit function and negative valence system behavioral abnormalities in treatment-resistant depression (TRD). The 5-year study, conducted by the Laureate Institute for Brain Research, Inc., will use low-intensity focused ultrasound (LIFU) neuromodulation to determine how connectivity between the...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research into the use of theta burst stimulation (TBS) to modulate hippocampal-cortical rhythms in schizophrenia. The $160,272 award to The Leland Stanford Junior University, covering the period from June 1, 2025 to May 31, 2027, will explore the use of invasive and non-invasive brain stimulation techniques to understand how TBS can influence...
- This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $638,872 to The Feinstein Institutes for Medical Research to conduct research on "Elucidating Reward Network Modulation in Medial Forebrain Bundle Deep Brain Stimulation for Treatment Resistant Depression". The goal is to use brain imaging to understand how deep brain stimulation of the medial forebrain bundle impacts the brain's reward processing...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is focused on understanding the neural mechanisms governing the acquisition, extinction, and renewal of fear and anxiety responses within the hippocampal-amygdala circuit in humans. The $211,248 award will enable the University of California, Los Angeles (UCLA) to conduct research using intracranial recording and stimulation of the human...
- This federal Project Grant award of $346,500.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), supports research aimed at selectively targeting and modulating cognitive control functions in the brain using transcranial electrical stimulation (TES). The research will measure the effects of spatiotemporally optimized TES on neural...
- This Project Grant award of $778,548.00, made by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to understand the neural mechanisms underlying social cognitive deficits in individuals with schizophrenia. The key objectives of this 5-year project are to: 1) investigate sensory processing dysfunctions in the third visual pathway, which is specialized for processing social information, and 2) explore the use of...
- The National Institute of Mental Health (NIMH) awarded Ampa Inc., a $1,199,261 project grant under the Mental Health Research Grants program (CFDA 93.242) to develop a next-generation Transcranial Magnetic Stimulation (TMS) system that improves upon current FDA-approved TMS treatments for depression. The key innovations of this system include: (1) precision TMS targeting based on neurocardiac response signals instead of functional MRI, (2) a camera and scalp cap system for neuronavigation rather...
- This National Institute of Mental Health (NIMH) Career Development Award (CFDA 93.242 - Mental Health Research Grants) will provide $188,976 to Dr. Drew Winters at the University of Colorado School of Medicine to conduct a clinical trial on the use of transcranial magnetic stimulation (TMS) for intervention development in psychopathy. The 5-year project (9/12/2025 - 8/31/2030) will enroll 60 adults aged 18-60 with psychopathy to test whether inhibitory TMS to the right dorsolateral prefrontal...
MAPPING A CAUSAL PREFRONTAL PATHWAY FOR AMYGDALA MODULATION UTILIZING INVASIVE AND NONINVASIVE BRAIN STIMULATION AND RECORDING METHODS IN HUMANS - PROJECT SUMMARY WHILE THE AMYGDALA IS A KEY FOCUS IN PSYCHIATRIC TREATMENTS AND INVASIVE MODULATION OF AMYGDALA ACTIVITY HAS SHOWN PROMISE IN TREATING CERTAIN REFRACTORY CASES, ITS WIDESPREAD USE AMONG MILLIONS OF TREATMENT-RESISTANT PATIENTS IS IMPRACTICAL AND ENTAILS INHERENT NEUROSURGERY-RELATED RISKS. THE DEVELOPMENT OF TRANSCRANIAL MAGNETIC STIMULATION (TMS) PROVIDES A POTENTIAL NONINVASIVE ALTERNATIVE. HOWEVER, THE EFFECTIVE MODULATION OF THE AMYGDALA WITH TMS IS HINDERED BY THE LACK OF KNOWLEDGE IN PINPOINTING A TMS-ACCESSIBLE CORTICAL SITE THAT CAN RELIABLY TARGET AND MODULATE THE AMYGDALA. THE DORSOLATERAL PREFRONTAL CORTEX (DLPFC) EMERGES AS A PROMISING CANDIDATE FOR STIMULATION BASED ON FINDINGS FROM EXTENSIVE PRELIMINARY DATA, PUBLISHED WORK, AND LARGE HUMAN CONNECTOME DATASETS. THE OVERALL OBJECTIVE IN THIS PROPOSAL TO DETERMINE WHETHER AND HOW DLPFC REPETITIVE STIMULATION MODULATES THE AMYGDALA ACTIVITY WITH AN UNPARALLELED COMBINATION OF INVASIVE AND NONINVASIVE STIMULATION AND RECORDING METHODS IN HUMANS. THE CENTRAL HYPOTHESIS IS THAT BOTH INVASIVE AND NONINVASIVE STIMULATION OF DLPFC MODULATE THE AMYGDALA ACTIVITY THROUGH THEIR FUNCTIONAL CONNECTIVITY MECHANISM. THIS CENTRAL HYPOTHESIS WILL BE TESTED BY PURSUING THREE SPECIFIC AIMS: DETERMINE INVASIVE MODULATORY EFFECTS OF INTRACRANIAL STIMULATION OF DLPFC ON THE AMYGDALA RECORDED WITH INTRACRANIAL EEG (IEEG) IN EPILEPSY PATIENTS (AIM 1), TRANSLATE STIMULATION WITH NONINVASIVE TMS OF DLPFC WHILE TRACKING MODULATORY EFFECTS ON THE AMYGDALA WITH IEEG IN EPILEPSY PATIENTS (AIM 2A) AND WITH FUNCTIONAL MRI IN HEALTHY INDIVIDUALS (AIM 2B), AND EVALUATE THE ROLE OF DLPFC-AMYGDALA FUNCTIONAL CONNECTIVITY IN PREDICTING MODULATORY EFFECTS OF DLPFC STIMULATION ON THE AMYGDALA (AIM 3). THE PROPOSED RESEARCH IS INNOVATIVE, BECAUSE IT CAN DETERMINE A UNIQUE CAUSAL PREFRONTAL PATHWAY FOR NONINVASIVE AMYGDALA MODULATION IN HUMANS. IT ALSO REPRESENTS THE FIRST ATTEMPT OF ANY GROUP WORLDWIDE TO CREATIVELY COMBINE MULTIMODAL CUTTING- EDGE BRAIN STIMULATION AND RECORDINGS TO COMPREHENSIVELY EVALUATE MODULATORY EFFECTS OF DLPFC STIMULATION ON THE HUMAN AMYGDALA. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE IT IS EXPECTED TO PROVIDE COMPELLING AND CONCLUSIVE CAUSAL EVIDENCE OF AMYGDALA MODULATION BY DLPFC STIMULATION AND INFORM A NOVEL CIRCUIT- BASED STRATEGY THAT CAN EFFICIENTLY PINPOINT A STIMULATION SITE WITHIN THE DLPFC FOR NONINVASIVE AMYGDALA MODULATION. ULTIMATELY, SUCH KNOWLEDGE WILL FACILITATE THE RATIONAL DESIGN OF PERSONALIZED, CIRCUIT-GUIDED NONINVASIVE NEUROMODULATORY THERAPIES AIMED AT MODULATING THE AMYGDALA FOR PSYCHIATRIC DISORDERS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $510.1k | 1/24/25 | ||
| Not listed | $60.5k | 6/6/24 | ||
| Not listed | $60.5k | 6/6/24 | ||
| Not listed | $544.3k | 4/19/24 | ||
| Not listed | $544.3k | 4/19/24 |