This $617,737 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of a thalamic-hippocampal pathway in suppressing and extinguishing contextual fear memories associated with post-traumatic stress disorder (PTSD). The project aims to use advanced imaging and manipulation techniques in head-fixed mice to uncover how the nucleus reuniens (NR) region of the thalamus interacts...
This $180,439 Project Grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support new mentored training in the computational neuroscience of higher-order threat learning and memory in post-traumatic stress disorder (PTSD). The primary objectives are to: 1) Apply multivariate pattern analysis to investigate how memory integration mechanisms facilitate threat generalization across higher-order pathways in brain...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research aimed at studying the structural and functional architecture of cortico-cerebellar systems in post-traumatic stress disorder (PTSD) and trauma exposure. The $610,152 award, spanning May 2025 to February 2029, will be conducted by Duke University to investigate the role of the cerebellum in PTSD pathophysiology, including...
This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), is funding a research project to investigate the circuit mechanisms underlying interactions between distinct learning systems. The $1,425,651 award, with a start date of July 18, 2024 and an ultimate completion date of March 31, 2029, is being provided to the University of Maryland, Baltimore to conduct this multi-level, interdisciplinary...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is for a research project titled "Intracranial Recording and Stimulation of the Human Hippocampal-Amygdala Circuit during Virtual Reality Fear Conditioning." The $211,248 award, effective March 1, 2025 through February 28, 2030, will support the University of California, Los Angeles (UCLA) in elucidating the neural mechanisms governing the...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to determine how model-based decision-making is represented in distinct cell types within the prelimbic cortex and dorsomedial striatum, two brain regions implicated in compulsive disorders. The $189,540 award, which runs from February 1, 2025 to January 31, 2030, will fund in vivo electrophysiology and optogenetics...
The federal Project Grant award R01MH133070, totaling $1,539,703, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The project aims to elucidate the mechanisms by which airway inflammation and immune mediators, specifically IL-17A, modulate fear regulation and brain function. Key research activities include: Determining if projections from the subfornical organ (SFO) to the infralimbic prefrontal cortex (IL-PFC)...
This federal Project Grant award of $444,125 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will investigate the role of serotonergic neurons in alterations to adult social behavior following early life adversity. The award, effective May 1, 2025 through April 30, 2027, will use the limited bedding and nesting model of early life adversity in mice to understand links between early experience, the serotonergic system, and social...
This Project Grant award of $545,759.00 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate how serotonin signaling in the medial prefrontal cortex of adolescent mice can modulate fear extinction and potentially inform new therapeutic approaches for anxiety disorders. The primary goals are to determine whether enhancing serotonin transmission in the infralimbic medial prefrontal cortex during adolescence can...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $133,488 to the University of California, Los Angeles (UCLA) to investigate the effects of early life adversity on the developmental trajectory of avoidance circuitry. The key objectives are to reveal the activity of early life adversity-sensitive neuron ensembles in the basolateral amygdala during threat avoidance behavior, map their brain-wide...