Project Grant R01LM015248
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $464,032 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for mapping intercellular circuits governing complex tissues, specifically mucosal epithelia in the intestine, airway, nose, urogenital tract, and related barrier surfaces. The project addresses two key analytical challenges: uncovering intercellular regulatory signals that...
- The National Cancer Institute awarded The Broad Institute, Inc. $694,642 on August 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to develop live-cell RNA sequencing with single-cell resolution. The project addresses a fundamental limitation in molecular omics measurement: current approaches require cell destruction through lysis, extraction, or fixation to detect molecular contents at high multiplexity, preventing serial measurement of living cells to monitor dynamic processes...
- The National Institutes of Health Office of the Director awarded The Broad Institute, Inc. $831,250 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop novel nanoprobes and advanced imaging techniques that extend single-molecule fluorescence microscopy capabilities in living cells. The project addresses fundamental limitations in visualizing G-protein-coupled receptor (GPCR) signal transduction. Current single-molecule imaging methods photobleach within...
- The National Cancer Institute awarded The Broad Institute, Inc., doing business as Broad Institute of MIT and Harvard, $245,297 on July 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop chimeric molecules that trigger generation of neoantigens from proteins dysregulated in infectious disease and cancer. The molecules will be formed by joining clinical-grade protein binders with reactive groups to generate neoantigens that recruit immune system...
- The National Science Foundation Division of Information and Intelligent Systems awarded $592,620 to Massachusetts Institute of Technology on July 1, 2026, under the Computer and Information Science and Engineering program (CFDA 47.070) to develop predictive models and feedback control mechanisms for CRISPR-based genetic circuits. The project addresses resource competition within modular CRISPRi/A systems used to engineer living cells to perform computational tasks—sensing signals, counting,...
- The National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, awarded The Broad Institute, Inc. $436,250 on May 1, 2026, under the NCATS program (CFDA 93.350) to develop and validate the RAPID (Rare Disease Analysis Through Pooled Image-Based Identification of Drugs) platform for drug repurposing in rare disorders. The Broad Institute will develop a massively parallel screening platform that integrates pooled optical variant identification,...
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $1,079,960 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to expand MicroTutor, an online platform for training biologists in quantitative bioimaging and bioimage analysis. MicroTutor delivers microscopy and bioimage analysis education through interactive learning technologies, combining short video lessons with interactive demonstrations and frequent mastery...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop lipid nanoparticle technology for simplified CRISPR/CAS9 gene editing in Caenorhabditis elegans nematodes. The funded work addresses a bottleneck in C. elegans research where microinjection of CRISPR guides limits throughput for genome-wide mutagenesis...
- The National Institute of Biomedical Imaging and Bioengineering awarded University of California, Berkeley $120,394 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop genome editing delivery vehicles that amplify editing efficiency by enabling cells to produce and distribute CRISPR-Cas9 editing enzymes to neighboring cells in vesicles. The research addresses inefficient delivery of genome editing to cell...
- The National Human Genome Research Institute awarded University of Massachusetts Medical School $418,750 on April 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop a cis-regulatory elements (CRE)-centric infrastructure in AnVIL for characterizing how genetic variation affects gene regulation. The project will establish a CRE workspace and analysis framework within the AnVIL cloud-based platform by integrating the ENCODE Registry of CREs to enable scalable, reproducible...
The National Institute of Environmental Health Sciences awarded The Broad Institute, Inc. $387,000 on August 1, 2026, under the Medical Library Assistance program (CFDA 93.879) to develop bioinformatics and computational methods for integrative structure-function analysis of CRISPR base-editor tiling mutagenesis experiments. The project will create scalable bioinformatics pipelines to link base-editor library data and screening results to protein sequence-structure-function relationships, enabling researchers to interpret high-throughput gene-editing experiments that introduce transition variants in cellular models. The work addresses challenges in harmonizing, normalizing, and aggregating results from multiple base-editor screens across different editors and cell lines, and extracting meaningful biological insights to identify drug-resistant mutations and clinically actionable pathogenic variants. The project is organized around two specific aims, each with two sub-aims, focused on building computational infrastructure to prioritize and interpret screening hits in the context of protein structure and function. Work is performed in Cambridge, Massachusetts. The period of performance runs from August 1, 2026, through May 31, 2030. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $387.0k | 8/4/26 |