Project Grant R35GM166090
Award Date 8/1/26
Completion Date 7/31/31
Dollars Obligated $464K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02142, USA
Similar Awards
- The National Institutes of Health Office of the Director awarded The Broad Institute, Inc. $831,250 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop novel nanoprobes and advanced imaging techniques that extend single-molecule fluorescence microscopy capabilities in living cells. The project addresses fundamental limitations in visualizing G-protein-coupled receptor (GPCR) signal transduction. Current single-molecule imaging methods photobleach within...
- The National Institute of Environmental Health Sciences awarded The Broad Institute, Inc. $387,000 on August 1, 2026, under the Medical Library Assistance program (CFDA 93.879) to develop bioinformatics and computational methods for integrative structure-function analysis of CRISPR base-editor tiling mutagenesis experiments. The project will create scalable bioinformatics pipelines to link base-editor library data and screening results to protein sequence-structure-function relationships,...
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $1,079,960 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to expand MicroTutor, an online platform for training biologists in quantitative bioimaging and bioimage analysis. MicroTutor delivers microscopy and bioimage analysis education through interactive learning technologies, combining short video lessons with interactive demonstrations and frequent mastery...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $433,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop network-based computational models for understanding continuous cell states in human development and disease. Over five years through February 28, 2031, the research group will create methods to integrate multiple modalities of large-scale genomics data, with emphasis on epigenetics and the...
- The National Cancer Institute awarded The Broad Institute, Inc. $694,642 on August 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to develop live-cell RNA sequencing with single-cell resolution. The project addresses a fundamental limitation in molecular omics measurement: current approaches require cell destruction through lysis, extraction, or fixation to detect molecular contents at high multiplexity, preventing serial measurement of living cells to monitor dynamic processes...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services, awarded $440,465 to the Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of genome folding and function. Over the five-year performance period ending February 28, 2031, the award funds research into chromosome architecture and the mechanisms that shape it—motor-driven loop...
- The National Institute of General Medical Sciences awarded Boston Children's Hospital $2.563 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to expand the biological capabilities of image-based transcriptomics by targeting short, homologous, and synthetic transcripts. The award funds development of multiplexed error-robust fluorescence in situ hybridization (MERFISH) methodology to overcome three key limitations of current image-based...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Boston $425,333 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular and molecular mechanisms of stem and progenitor cell development during tissue homeostasis and after injury. The research uses the Drosophila melanogaster blood system as a model to examine how multiple cell types within stem and progenitor cell niches use inflammatory...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $899,250 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new computational-experimental approaches for measuring and modeling gene expression trajectories at the single-cell level. The research integrates experimental systems biology and genomics with machine learning and data science to track RNA production, processing, and degradation rates....