Project Grant R01HL185831
- This $197,600 Project Grant, awarded September 5, 2025, by the National Heart, Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), funds mechanistic research into premature calcification in bicuspid aortic valve (BAV) disease at The Medical College of Wisconsin, Inc. The research investigates how abnormal mechanical stress induced by BAV—the most prevalent congenital heart disease affecting approximately 2% of the global population—promotes...
- Federal Grant Award Summary Baylor College of Medicine received a $248,993 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 1, 2026 through April 30, 2029. The award funds the development of metasurface optical guidewires for percutaneous coronary intervention (PCI) procedures in patients with coronary artery calcification (CAC). The research deliverables include design and manufacturing of...
- Federal Grant Award Summary Baylor College of Medicine received a $773,868 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with a completion date of June 30, 2030. The award funds research to elucidate the mechanisms regulating inflammation in developing lungs, with a focus on regulatory T cells (Tregs) and their role in bronchopulmonary dysplasia-associated pulmonary...
- Federal Project Grant Award Summary Baylor College of Medicine received a $128,341 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 23, 2025, with completion anticipated by August 31, 2027. The grant funds research investigating the role of de novo nucleotide synthesis in endothelial cells and atherosclerosis development. Specifically, the project examines how two critical enzymes—ATIC...
- Federal Project Grant Award Summary Baylor College of Medicine received a $1.60M project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with completion scheduled for April 30, 2028. The grant funds basic research investigating the role of the let-7 microRNA/EZH2/BACH1 double negative feedback loop in alveolar cell-induced interstitial lung disease (ILD). The research addresses a critical...
- Federal Grant Award Summary Baylor College of Medicine received a $673,598 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with a completion date of June 30, 2029. The project, "Cardiomyocyte-Fibroblast Signaling in Atrial Fibrillation," delivers basic and translational research services investigating molecular mechanisms underlying atrial fibrillation (AF), a...
- Federal Project Grant Award Summary Baylor College of Medicine received a $240,707 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026 through April 30, 2028. This limited R03 award funds research into the mechanisms of marginal zone B cell depletion in sickle cell disease (SCD) spleen tissue, with the objective of identifying genes critical to B cell development and immune dysfunction in...
- Federal Project Grant Award Summary Baylor College of Medicine received a $508,290 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through March 31, 2030. The award funds mechanistic research investigating the role of BHLHE40 in orchestrating mucosal CD8 T cell responses in sarcoidosis lungs. The research addresses critical knowledge gaps in sarcoidosis pathogenesis by examining CD8...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Baylor College of Medicine a $613,399 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) on September 16, 2025, to develop machine learning (ML)–enabled clinical decision support (CDS) tools for early detection and mitigation of acute kidney injury (AKI) following cardiac surgery. The project, which extends through June 30, 2029, will deliver personalized ML algorithms that...
- Federal Project Grant Award Summary Baylor College of Medicine received a $752,618 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 2, 2025, through May 31, 2030. The grant supports research investigating the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery occurring in 10-50% of patients. The research utilizes a...
Baylor College of Medicine received a $720,103 Project Grant award dated July 15, 2026, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds basic and translational research investigating the mechanisms of vascular calcification in chronic kidney disease (CKD) patients, a major cardiovascular risk factor. The research deliverables include mechanistic studies examining how endothelial cell JAGGED1 deficiency contributes to arterial calcification through identification and characterization of CLEC3B as a downstream signaling protein that binds calciprotein particles to inhibit hydroxyapatite formation and extracellular matrix mineralization. The project employs mouse CKD models, arteriovenous fistula models, and ex vivo endothelial-smooth muscle cell co-culture systems to generate molecular and cellular research outputs, supported by advanced analytical methods including single-cell RNA sequencing, proteomics analysis, and serological biomarker assessment. The work is scheduled for completion by March 31, 2030, and is expected to generate foundational knowledge regarding the role of endothelial cell signaling in regulating vascular calcification, potentially informing future therapeutic interventions for this currently undertreated complication of CKD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $720.1k | 7/7/26 |