Project Grant R00HL173631
- Federal Grant Award Summary Baylor College of Medicine received a $673,598 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with a completion date of June 30, 2029. The project, "Cardiomyocyte-Fibroblast Signaling in Atrial Fibrillation," delivers basic and translational research services investigating molecular mechanisms underlying atrial fibrillation (AF), a...
- Federal Project Grant Award Summary Baylor College of Medicine received a $752,618 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 2, 2025, through May 31, 2030. The grant supports research investigating the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery occurring in 10-50% of patients. The research utilizes a...
- Federal Grant Award Summary Baylor College of Medicine received a $1,279,044 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion scheduled for May 31, 2030. This R01 award funds mechanistic research to elucidate how cardiac tissue-resident macrophages (TRMs) contribute to adverse cardiac remodeling and heart failure (HF) progression. The research project will deliver...
- Federal Grant Award Summary Award Details: Baylor College of Medicine received a $773,868 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of June 30, 2030. The research will be conducted in Houston, Texas. Research Objectives and Deliverables: This project investigates the mechanistic and therapeutic roles of regulatory T cells (Tregs) in bronchopulmonary...
- Federal Project Grant Award Summary Baylor College of Medicine received a $128,341 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 23, 2025, with completion anticipated by August 31, 2027. The grant funds research investigating the role of de novo nucleotide synthesis in endothelial cells and atherosclerosis development. Specifically, the project examines how two critical enzymes—ATIC...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $197,600 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on September 5, 2025, with completion scheduled for March 31, 2029. The award funds research investigating the mechanosensitive mechanisms of premature calcification in bicuspid aortic valve (BAV) disease, the most prevalent congenital heart disease affecting...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research program (CFDA 93.837), awarded Baylor College of Medicine a $1,399,817 Project Grant on August 22, 2025, to develop innovative risk prediction models for venous thromboembolism (VTE) and bleeding complications in cancer patients undergoing chemotherapy. The research addresses a critical clinical gap: while direct oral anticoagulants (DOACs) are evidence-supported for...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute awarded the University of California, Irvine a $617,366 Project Grant on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop an integrated intravascular imaging system for studying coronary artery disease and atherosclerotic plaque vulnerability. The research addresses the critical clinical need for early detection and characterization of vulnerable plaques, which are the primary...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Project Grant Award Summary Baylor College of Medicine received a $240,000 Project Grant from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for July 31, 2027. This research project investigates the epigenetic mechanisms through which thoracic aortic aneurysm and dissection (TAAD)-associated single nucleotide polymorphisms (SNPs) contribute to disease susceptibility in...
Baylor College of Medicine received a $248,993 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 1, 2026, with completion targeted for April 30, 2029. The award funds development of novel metasurface optical guidewires designed to improve percutaneous coronary intervention (PCI) outcomes in patients with coronary artery calcification (CAC). The research addresses a significant clinical challenge whereby CAC reduces vessel compliance and complicates stent deployment and expansion, frequently resulting in treatment failure through restenosis or stent thrombosis. The project deliverables encompass three primary components: design and manufacturing of sub-millimeter metasurface optics for optical guidewires; development of optimized PCI workflows for laser-induced intravascular lithotripsy; and evaluation of long-term treatment efficacy in preclinical animal models. The optical guidewires will be guided by multimodal imaging modalities to provide enhanced diagnostic and monitoring capabilities. Upon successful completion, the research is expected to yield innovative medical devices and therapeutic procedures that significantly improve PCI outcomes, reduce procedure complications, and advance clinical management of calcified coronary arteries.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 5/25/26 |