Project Grant R01HL179285
- Federal Grant Award Summary Baylor College of Medicine received a $773,868 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with a completion date of June 30, 2030. The award funds research to elucidate the mechanisms regulating inflammation in developing lungs, with a focus on regulatory T cells (Tregs) and their role in bronchopulmonary dysplasia-associated pulmonary...
- Federal Project Grant Award Summary Baylor College of Medicine received a $1.60M project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with completion scheduled for April 30, 2028. The grant funds basic research investigating the role of the let-7 microRNA/EZH2/BACH1 double negative feedback loop in alveolar cell-induced interstitial lung disease (ILD). The research addresses a critical...
- Federal Project Grant Award Summary Baylor College of Medicine received a $240,707 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026 through April 30, 2028. This limited R03 award funds research into the mechanisms of marginal zone B cell depletion in sickle cell disease (SCD) spleen tissue, with the objective of identifying genes critical to B cell development and immune dysfunction in...
- Federal Grant Award Summary Baylor College of Medicine received a $1.58 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of May 31, 2030. The award funds research investigating the detrimental effects of the B-cell-Th17 (T helper 17) axis on antiviral immunity in smokers. The research team will conduct mechanistic studies to determine how cigarette...
- Federal Project Grant Award Summary The University of Illinois at Chicago received a $174,560 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 1, 2026, through May 31, 2030. The award funds research investigating the immunological mechanisms underlying sarcoidosis, a rare granulomatous lung disease characterized by dysregulated immune response and chronic inflammation. The research project...
- Federal Project Grant Award Summary Baylor College of Medicine received a $752,618 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 2, 2025, through May 31, 2030. The grant supports research investigating the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery occurring in 10-50% of patients. The research utilizes a...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Feinstein Institutes for Medical Research a Project Grant of $586,866 under the Cardiovascular Diseases Research program (CFDA 93.837) on May 15, 2026, with a completion date of February 28, 2030. This award funds research investigating the critical role of B-1A cells, an immunoregulatory B cell subset, in mitigating acute lung injury (ALI) and acute respiratory distress...
- Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Washington University a Project Grant of $1.9M (awarded June 15, 2026; completion February 28, 2028) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct fundamental mechanistic research addressing chronic muco-obstructive lung disease. The research identifies and corrects a pathological reprogramming pathway in basal epithelial stem cells (basal-ESCs) that drives persistent airway...
- Federal Grant Award Summary The University of Illinois at Chicago received a $173,480 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 20, 2025, with completion targeted for August 31, 2030. The project, "Uncovering the Inflammatory-Fibrotic Axis in Pulmonary Sarcoidosis," will deliver research services focused on identifying and characterizing the mechanisms by which...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Washington University a Project Grant totaling $169,140 effective July 1, 2026, through April 30, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds mechanistic research investigating immuno-metabolic drivers of chronic rejection following lung transplantation, specifically addressing bronchiolitis obliterans syndrome (BOS)—the major cause of death occurring one...
Baylor College of Medicine received a $508,290 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through March 31, 2030. The award funds mechanistic research investigating the role of BHLHE40 in orchestrating mucosal CD8 T cell responses in sarcoidosis lungs. The research addresses critical knowledge gaps in sarcoidosis pathogenesis by examining CD8 intraepithelial lymphocytes (IELs) in lung tissue and their contribution to both fibrosis-promoting and fibrosis-suppressing mechanisms, utilizing a preclinical mouse model and human lung tissue analysis to bridge translational science. The project deliverables include scientific research outputs examining CD8 T cell biology in the context of interstitial lung disease, transcriptomic and flow cytometric analyses of human lung tissue, and characterization of a CD8 IEL subpopulation implicated in sarcoidosis pathogenesis. This fundamental science research is expected to generate new mechanistic understanding of how CD8 T cells contribute to disease progression and potential fibrosis outcomes in sarcoidosis, contributing to NHLBI's mission to advance knowledge of lung diseases and foster hypothesis-driven research across translational pathways.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $508.3k | 7/7/26 |