This Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the functional role and significance of the junctophilin-1 (JP1) protein in the heart. The $684,937 award to the University of Iowa will support research activities over a 4-year period from March 2025 to December 2028. The key objectives of this project are to:
- Determine the structural and functional consequences of depleting JP1 from cardiomyocytes.
- Define the mechanism by which JP1 regulates cardiomyocyte structure and function.
- Investigate the mechanism and significance of JP1 dysregulation during cardiac stress.
This research project leverages the university's expertise and unique mouse models to further the understanding of JP1's role in cardiac function and its potential implications for heart disease. The findings have the potential to provide fundamental insights into the mechanisms underlying cardiac regulation and inform future therapeutic approaches.
Generated 3/25/25, 3:24 AM