Project Grant R01HL180520
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $811,885 in funding to the J. David Gladstone Institutes in California to conduct research on epigenomic mechanisms of cardiac fibrosis and heart failure. The project aims to investigate the role of the MEOX1 gene as a key transcriptional regulator of fibroblast activation, fibrosis, and heart failure pathogenesis. The research leverages novel genetic mouse...
- This federal Project Grant award of $772,808 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of cardiac metabolism and glutamine production in heart failure and cardiac fibrosis. The project, led by Temple University, aims to investigate whether cardiomyocyte glutamine production plays a pivotal role in fibroblast activation and cardiac fibrosis. Key research activities include generating a cardiomyocyte-specific...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- The federal Project Grant award of $726,452 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to model intra- and inter-cellular networks involved in TRPC6-dependent cardiac fibrosis. The award aims to leverage computational methods and multi-scale experiments to better understand how TRPC6 signaling drives myofibroblast transformation and fibrosis in response to cardiac and dermal wounds. The research will be conducted by the...
- The federal Project Grant award of $651,009 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Iowa to investigate the role of the protein junctophilin-2 (JP2) in regulating calcium signaling in cardiac fibroblasts and its impact on cardiac fibrosis. The project aims to employ advanced molecular, physiological, and biochemical techniques, along with innovative mouse models, to elucidate the specific...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Albert Einstein College of Medicine provides $785,198 in funding to study the role of chaperone-mediated autophagy (CMA) in regulating cardiac fibroblast and myofibroblast function during heart repair following myocardial infarction. The research aims to investigate how CMA, a selective protein degradation process, modulates fibroblast phenotypic transitions and impacts...
- This Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $655,636 in funding to the Texas Heart Institute (THI) to investigate the role of cardiac fibroblasts in the development of heart failure in patients with single ventricle congenital heart disease. The objectives are to gain insights into the intrinsic molecular mechanisms that promote cellular senescence, metabolic remodeling, and...
- The University of Utah was awarded a $756,947 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on March 10, 2025. The project aims to improve and better understand the factors that influence spin-locking cardiac MRI for assessing myocardial fibrosis, a key indicator of cardiovascular disease. The key objectives are to: 1) study the value of different T1rho MRI methods and conventional techniques in preclinical models of diffuse and...
- The University of Utah was awarded a $654,530 project grant from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of the serine-threonine kinase SGK1 in cardiometabolic heart failure with preserved ejection fraction (CMET HFPEF). The project will run from September 1, 2025 to July 31, 2029 and aims to advance understanding of the mechanisms by which SGK1 regulates cellular metabolism in CMET HFPEF, a prevalent form of heart...
- The Project Grant award of $639,621 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM) to investigate mitochondrial signaling between cardiomyocytes and fibroblasts, and its role in cardiac fibrosis. The research aims to determine how cardiomyocyte-derived mitochondria mediate crosstalk with cardiac fibroblasts, which may underlie the...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the University of Utah provides $745,663 to investigate the role of the IRE1 protein in regulating cardiac fibrosis, a key mechanism underlying heart failure. The research aims to elucidate how the unfolded protein response (UPR) in cardiac fibroblasts affects their activation and production of extracellular matrix proteins during the progression of both reduced and preserved ejection fraction heart failure. The project will characterize a novel small molecule activator of IRE1 with potential to mitigate pathological cardiac fibrosis. This 4-year research effort, beginning September 1, 2025 and concluding on June 30, 2029, seeks to advance the mechanistic understanding of UPR signaling in cardiac fibrosis and identify new therapeutic strategies to address the leading cause of mortality in the U.S.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $745.7k | 8/28/25 |