Project Grant R01HL181272
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will fund research to investigate place-based factors contributing to sleep health disparities in the United States. The $177,385 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will: 1) Estimate sleep health measures and environmental circadian misalignment across different populations and geographies; 2) Examine...
- This Project Grant award for $730,993.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms by which internal circadian misalignment contributes to the cardiometabolic risk associated with sleep loss. The project aims to determine if preventing light exposure and food intake during the circadian biological night can mitigate the adverse cardiometabolic effects of insufficient sleep. Researchers at...
- This Project Grant award in the amount of $885,349.00, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports the development of a blood test to measure sleep deprivation and circadian time. The award was made to Brigham & Women's Hospital Inc., a prominent academic medical center and research institution that is a subsidiary of Partners Healthcare System (Mass General Brigham). The performance period for this research...
- This $691,124.00 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The project aims to test the hypothesis that persistent circadian disruption, including misaligned sleep, eating, and activity timing, will be related to the development of cardiometabolic risk through epigenetic...
- This federal Project Grant award, valued at $678,710 and awarded on June 15, 2025, was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports the development and validation of a novel multi-sensor machine learning approach to precision sleep tracking for nightshift workers. The project aims to leverage wearable devices, environmental sensors, and machine learning algorithms to accurately detect sleep patterns...
- This $281,560 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports mathematical modeling research to investigate peripheral metabolic circadian rhythms and their implications for managing shift work and jet lag. The project aims to develop and validate models for peripheral circadian rhythms, which may underlie short-term gastrointestinal symptoms and longer-term...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $594,547 to Harvard Medical School to conduct research on the regulation of arousal and sleep quality. The project aims to characterize a gut-to-brain signaling pathway that uses information about ingested nutrients to control arousal levels and sleep depth, without affecting overall sleep duration. The research will investigate...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $818,279 to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on improving the subtyping and characterization of obstructive sleep apnea (OSA). The project will leverage data from existing research cohorts and a clinical biobank to quantify the reproducibility of OSA severity markers and derive physiologically...
- This federal Project Grant award, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a comprehensive sleep neuroimaging study to investigate the role of local sleep disturbance in obesity risk. The $568,125 award to Brigham Young University, with a period of performance from September 2025 to August 2028, will utilize advanced functional neuroimaging and polysomnographic methods to elucidate the underlying mechanisms linking poor...
- This federal Project Grant award, valued at $755,257.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award aims to study the role of GPI-anchor biosynthesis in regulating sleep, with the goal of improving understanding of the genetic factors underlying sleep disorders such as insomnia. The research will be conducted by Texas A&M University and will involve a multi-pronged approach, including...
This federal Project Grant award, totaling $1,621,874.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) with an award date of Sep 23, 2025 and an ultimate completion date of Jun 30, 2027. The award was granted to Brigham & Women's Hospital Inc., a subsidiary of the larger Partners Healthcare System (now Mass General Brigham), to conduct research on the role of ambient lighting in circadian misalignment and its impact on sleep, cognition, and central oxidative stress in a chronic variable sleep deficiency paradigm. The research aims to address the critical knowledge gap in understanding the mechanistic pathways by which irregular sleep schedules promote cognitive impairment and neurodegenerative disease. The project will explore the potential of sleep- and circadian-informed lighting (SCIL) as a countermeasure to attenuate the negative effects of chronic variable sleep deficiency.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 9/22/25 |