Project Grant R01HL180613
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- This $1,332,404 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of basolateral endothelial cilia in promoting vascular stability in the brain. The awardee, The Medical College of Wisconsin, Inc., will investigate the hypothesis that basolateral endothelial cilia facilitate cell-cell communication with pericytes to regulate vascular stability through signaling pathways involving PDGF-BB, heparan...
- This Project Grant award, valued at $748,965.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Northwestern University for a research project titled "Vascular Proliferative Resilience - Summary in Adults". The project aims to investigate the dynamics, spatial context, and molecular regulators of endothelial cell proliferation in the aorta, with the goal of deciphering the mechanisms underlying the maintenance of vascular...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the mechanosensitive mechanisms underlying angiogenesis and lung regeneration. The $618,838 award to the Medical College of Wisconsin aims to investigate how mechanical stretching forces control angiogenesis during compensatory lung growth after pneumonectomy. The research will focus on the role of the focal adhesion protein paxillin in regulating...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to define the role of the RNA-binding protein G3BP1 in blood vessel formation. The $147,486 award to Yale University will fund the development of a novel zebrafish model to investigate how G3BP1-mediated post-transcriptional regulation impacts vascular development. The overall objective is to enhance understanding of the gene regulatory networks...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $775,720 project grant to Yale University under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to conduct research on the role of endothelial protocadherins in vascular development and disease. The project aims to: 1) determine the effects of knocking out or inhibiting the protocadherin gamma (PCDHG) cluster in endothelial cells in mouse models of vascular inflammation, 2) elucidate the mechanism by which...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) totaling $706,220.00 supports research to elucidate the role of the nuclear pore protein NUP93 in regulating endothelial cell function and vascular health. The research aims to investigate how phosphorylation of NUP93 by the AKT signaling pathway impacts YAP localization and endothelial inflammation, as well as the in vivo importance of NUP93 phosphorylation in...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- This Project Grant award of $720,526 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of the TBC1D2B protein in the formation of new blood vessels and vascularization after ischemic injury. The funded research aims to uncover the underlying regulatory mechanisms by which the TBC1D2B protein, which interacts with phosphatidylinositol lipids, impacts the formation of endothelial cell tubes crucial for...
- This $639,822 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to determine the role of neutral sphingomyelinase (nSMase), a membrane enzyme involved in lipid signaling, in the mechanical regulation of the heart. The research aims to investigate how nSMase contributes to normal cardiac function under acute changes in load, as well as its role in the deterioration of cardiac function during chronic overload...
This Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify key regulators of vascular homeostasis and understand how they maintain normal vascular function. The principal investigators at the Medical College of Wisconsin are focusing on understanding the role of the RNA-binding protein PABPC1 in suppressing endothelial cell activation and inflammation to prevent the loss of vascular homeostasis in cardiovascular diseases. The research involves generating induced endothelial cell-specific knockout mice of PABPC1 to study the resulting loss of vascular homeostasis, systemic inflammation, immune cell infiltration, and vascular leakage. This work aims to elucidate the mechanisms by which PABPC1 regulates vascular homeostasis, with the long-term goal of understanding how key homeostasis factors can confer resilience to the vasculature and prevent cardiovascular diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $618.5k | 7/29/25 |