This $108,405 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), funded under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of primary cilia in regulating vascular stability during embryonic development. The key objectives are to: 1) assess how endothelial cell primary cilia respond to changes in hemodynamic forces, 2) determine the influence of primary cilia on mural cell recruitment, differentiation,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $717,236 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Iowa to study the role of neuronal primary cilia in hypertension, autonomic dysfunction, and body fluid imbalance. The key products and services to be delivered under this 4-year grant include: Evaluating how conditional ablation of cilia in the supraoptic nucleus affects blood pressure, drinking, urine volume, sodium concentration, plasma...
This $827,665 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837) supports research to develop scalable methods for identifying causal genetic variants, relevant cell types, and target genes that influence cardiovascular disease (CVD) risk. The key products and services to be delivered include: Performing colocalization of CVD and blood cell trait genome-wide association studies (GWAS) to...
This $375,988 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to examine the interactions between endothelial cells and mural cells in capillary malformations. The principal investigator will use human endothelial cells expressing the R183Q mutation in the GNAQ gene, which is linked to capillary malformations, to (1) identify paracrine interactions between these mutant endothelial...
This federal Project Grant award, totaling $2,218,392.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The primary objective is to investigate the role of the lymphatic system and its coupling with the glymphatic system in the pathogenesis of cerebral small vessel disease (CSVD) in the context of chronic hypertension. Key activities include: Characterizing lymphatic drainage and glymphatic transport...
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) awarded a $1,152,560 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Washington University in St. Louis to study the role of the NRF2 pathway and glutathione system in maintaining normal and dyskinetic motile cilia function. The 5-year project aims to characterize the glutathione system in motile cilia and determine how the KEAP1-NRF2 transcriptional program regulates cilia...
This federal Project Grant award of $127,305, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to understand the interactions between mutant endothelial cells, mural cells, and macrophages in capillary malformations. The key research activities include: 1) Determining the role of macrophages in capillary malformations with mosaic endothelium, and 2) Characterizing the interactions between...
The National Institutes of Health National Heart Lung and Blood Institute awarded a $511,680 Project Grant to the University of Illinois under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will fund research from February 2021 through August 2021 to investigate mechanisms by which vascular endothelial cells instruct macrophage fate in inflammatory injury. Specifically, the research will examine how endothelial cell Wnt signaling licenses the differentiation of monocytes...
This Project Grant award in the amount of $493,810 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports research at the University of Wisconsin-Madison to investigate the role of cellular interactions and microenvironmental signals in programming hematopoietic stem and progenitor cells (HSPCs) during development and migration. Specific aims include determining how vascular...
The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $294,993 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Sensoriis Inc. located in Edmonds, WA. The project aims to develop a Zebrafish Automatic Cardiovascular Assessment System (ZACAS) to enable fast, economic, and reliable assessment of cardiac function in developing zebrafish embryos. The system will include novel housing chambers, camera...