Project Grant R01HL179583

Award Date 5/1/25
Completion Date 3/31/29
Dollars Obligated $671K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Milwaukee, WI 53226, USA
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Evaluating the localization and role of platelet-derived growth factor-BB (PDGF-BB) in the context of the extracellular matrix and basolateral endothelial cell cilia, investigating how basolateral endothelial cell cilia facilitate pericyte recruitment, and determining if the interface between endothelial cell cilia and heparan sulfate proteoglycans promotes brain vascular stability. The research will utilize zebrafish, mouse, and primary human brain microvascular endothelial cell models, employing genetic manipulation, gain- and loss-of-function strategies, and microfluidic co-culture systems. The goal is to understand the mechanisms of basolateral endothelial cell-pericyte communication and its implications for interventions in conditions with compromised vascular stability.

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