Project Grant R01HL178787
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) totaling $706,220.00 supports research to elucidate the role of the nuclear pore protein NUP93 in regulating endothelial cell function and vascular health. The research aims to investigate how phosphorylation of NUP93 by the AKT signaling pathway impacts YAP localization and endothelial inflammation, as well as the in vivo importance of NUP93 phosphorylation in...
- This federal Project Grant award of $701,791 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of neddylation, a post-translational modification, in protecting endothelial cell integrity and function. The research aims to establish the pathophysiological significance of neddylation in the endothelium and identify key downstream effectors. The University of Nebraska, Lincoln is the awardee and will utilize...
- This Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify key regulators of vascular homeostasis and understand how they maintain normal vascular function. The principal investigators at the Medical College of Wisconsin are focusing on understanding the role of the RNA-binding protein PABPC1 in suppressing endothelial cell activation and inflammation to prevent the loss of vascular...
- The National Institutes of Health National Heart Lung and Blood Institute awarded a $511,680 Project Grant to the University of Illinois under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will fund research from February 2021 through August 2021 to investigate mechanisms by which vascular endothelial cells instruct macrophage fate in inflammatory injury. Specifically, the research will examine how endothelial cell Wnt signaling licenses the differentiation of monocytes...
- The federal Project Grant award of $701,890.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the molecular mechanisms by which the cancer drug sunitinib induces vascular dysfunction. The University of Illinois in Chicago is conducting this research, which aims to better understand sunitinib's effects on the endothelial cells that line blood vessels, in order to mitigate the risk of cardiovascular toxicity...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
- The National Heart, Lung, and Blood Institute awarded a $2,183,648 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to Northwestern University to conduct research focused on the role of macrophage phagocytes in cardiac inflammation and disease. The project aims to identify key immunometabolic signaling pathways that contribute to chronic cardiac inflammation, particularly in the context of heart failure. The research will examine how risk factors...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports the development of a lesion-targeted nanotherapeutic to address vascular smooth muscle cell (VSMC) dysfunction and mitigate neointimal hyperplasia (NIH), which is a significant issue arising from vascular damage during interventions. The project aims to integrate in vitro transcribed CARMN RNA (a long non-coding RNA critical...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $790,498 to the University of Southern California (USC) for a research project entitled "Targeting PCBP1 to Ameliorate Pathological Angiogenesis". The grant, which runs from September 1, 2025 to June 30, 2030, aims to investigate the role of the PCBP1 protein and its target AARS2 in regulating vascular endothelial growth factor (VEGF) signaling and...
This Project Grant award, valued at $748,965.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Northwestern University for a research project titled "Vascular Proliferative Resilience - Summary in Adults". The project aims to investigate the dynamics, spatial context, and molecular regulators of endothelial cell proliferation in the aorta, with the goal of deciphering the mechanisms underlying the maintenance of vascular integrity. The research will utilize a novel mouse model to study the compensatory proliferative response following endothelial cell death, and explore potential pharmacological interventions to modulate this process. This work seeks to address a previously unrecognized deterioration in the ability of large blood vessels to maintain adequate regulation of vascular integrity, which has implications for cardiovascular health. The award period is from September 1, 2025 to May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $749.0k | 9/1/25 |