Project Grant R01HL182084
- This $713,511 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the impact of myosin-binding protein C (MyBP-C) on myosin mobility and proteostasis in the context of hypertrophic cardiomyopathy (HCM). The University of Vermont & State Agricultural College, the awardee, will utilize innovative techniques to investigate how reduced MyBP-C levels, a common cause of HCM, may disrupt normal heart...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- The Texas A&M University System Health Science Center received a $542,663 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the mechanistic role of small Rho GTPase in chronic cardiac fibrotic remodeling. The research aims to explore the dynamic function of fibroblast RhoE in post-myocardial infarction cardiac remodeling, with the goal of selectively mitigating prolonged fibrosis without interrupting...
- This $761,152 project grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of California, San Diego (UCSD) to investigate the gene regulatory mechanisms controlling the expression of cardiac myosin heavy chain proteins. The goal is to understand how shifts in the ratio of the MYH6 and MYH7 isoforms impact cardiac contractility, which is critical for heart function under both normal and disease...
- This Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify key regulators of vascular homeostasis and understand how they maintain normal vascular function. The principal investigators at the Medical College of Wisconsin are focusing on understanding the role of the RNA-binding protein PABPC1 in suppressing endothelial cell activation and inflammation to prevent the loss of vascular...
- This $548,816 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to investigate the role of the SEC16B protein in regulating lipid metabolism and transport in the liver. The project aims to define how SEC16B mediates the formation of lipid droplets and very low-density lipoprotein (VLDL) secretion, which are key processes involved in cholesterol and triglyceride homeostasis. This...
- The University of Iowa was awarded a $612,186 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the role of the lysosome in heart failure with preserved ejection fraction (HFPEF). The project aims to determine the pathophysiological impact of cardiac lysosomal dysfunction in HFPEF, which accounts for half of heart failure hospitalizations in the U.S. The research will investigate how the lysosomal protein GILT...
- The University of Cincinnati was awarded a $698,432 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on "Stress Regulated RNA Degradation in Cardiac Hypertrophy." The project aims to establish the role of the UPF1 RNA helicase and the RBFOX1C RNA binding protein in regulating mRNA degradation in response to cardiac stress, and to determine the functional significance of this stress-regulated mRNA...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
This $639,822 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to determine the role of neutral sphingomyelinase (nSMase), a membrane enzyme involved in lipid signaling, in the mechanical regulation of the heart. The research aims to investigate how nSMase contributes to normal cardiac function under acute changes in load, as well as its role in the deterioration of cardiac function during chronic overload conditions associated with heart failure. The findings are expected to elucidate key signaling pathways underlying cardiac mechanosensing and mechano-chemical transduction, and identify nSMase as a potential therapeutic target for mitigating the deleterious effects of cardiac pressure overload. The grant was awarded to the University of Wisconsin System, a leading public research institution, which will conduct this research at the University of Wisconsin-Madison.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $639.8k | 9/9/25 |