Project Grant R01HL176954
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to define the role of the RNA-binding protein G3BP1 in blood vessel formation. The $147,486 award to Yale University will fund the development of a novel zebrafish model to investigate how G3BP1-mediated post-transcriptional regulation impacts vascular development. The overall objective is to enhance understanding of the gene regulatory networks...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate...
- This Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify key regulators of vascular homeostasis and understand how they maintain normal vascular function. The principal investigators at the Medical College of Wisconsin are focusing on understanding the role of the RNA-binding protein PABPC1 in suppressing endothelial cell activation and inflammation to prevent the loss of vascular...
- The federal Project Grant award titled "Lysosomal Ionic Dysregulation in Heart Disease" was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Temple University-Of The Commonwealth System Of Higher Education in Philadelphia, PA. The $717,558 award, which runs from September 4, 2025 to June 30, 2030, will support research to investigate the role of the lysosomal two-pore channel (TPC2) in promoting cardiomyocyte death and impaired...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $790,498 to the University of Southern California (USC) for a research project entitled "Targeting PCBP1 to Ameliorate Pathological Angiogenesis". The grant, which runs from September 1, 2025 to June 30, 2030, aims to investigate the role of the PCBP1 protein and its target AARS2 in regulating vascular endothelial growth factor (VEGF) signaling and...
- This Project Grant award, valued at $748,965.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Northwestern University for a research project titled "Vascular Proliferative Resilience - Summary in Adults". The project aims to investigate the dynamics, spatial context, and molecular regulators of endothelial cell proliferation in the aorta, with the goal of deciphering the mechanisms underlying the maintenance of vascular...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $410,449 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The Leland Stanford Junior University (Stanford University) on August 1, 2025. The funding supports research to develop novel synthetic biology strategies that would enable the quantitative and dynamic regulation of growth factors and cytokines produced from human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs). The goal...
- The Project Grant award of $2,868,266.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Temple University to investigate the role of the vascular enzyme pyruvate kinase M2 (PKM2) in mediating hypertension and vascular remodeling. The project aims to explore how angiotensin II-induced activation of PKM2 in vascular smooth muscle cells contributes to hypertension and remodeling of both conductance and...
- This Project Grant award of $528,179, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research conducted by the University of Miami to investigate reprogramming of monocytes to improve neovascularization in peripheral arterial disease and critical limb ischemia. The key objectives are to: 1) determine if extracellular vesicles mediate the systemic effects of monocyte reprogramming, and 2) investigate how reduced expression of the...
This Project Grant award of $720,526 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of the TBC1D2B protein in the formation of new blood vessels and vascularization after ischemic injury. The funded research aims to uncover the underlying regulatory mechanisms by which the TBC1D2B protein, which interacts with phosphatidylinositol lipids, impacts the formation of endothelial cell tubes crucial for vessel integrity and function. Key research activities include mass spectrometry analysis to identify TBC1D2B-interacting proteins, in vitro experiments to assess the role of TBC1D2B in endothelial tube formation, and in vivo studies using zebrafish models to evaluate the impact of TBC1D2B on blood vessel development. The award is held by the Trustees of the University of Pennsylvania, a leading private research institution, and the project will be conducted from September 2025 through June 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $720.5k | 8/18/25 |