Project Grant R01HL180575
- Federal Grant Award Summary Baylor College of Medicine received a $773,868 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with a completion date of June 30, 2030. The award funds research to elucidate the mechanisms regulating inflammation in developing lungs, with a focus on regulatory T cells (Tregs) and their role in bronchopulmonary dysplasia-associated pulmonary...
- Federal Project Grant Award Summary Baylor College of Medicine received a $508,290 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through March 31, 2030. The award funds mechanistic research investigating the role of BHLHE40 in orchestrating mucosal CD8 T cell responses in sarcoidosis lungs. The research addresses critical knowledge gaps in sarcoidosis pathogenesis by examining CD8...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Feinstein Institutes for Medical Research a Project Grant of $586,866 under the Cardiovascular Diseases Research program (CFDA 93.837) on May 15, 2026, with a completion date of February 28, 2030. This award funds research investigating the critical role of B-1A cells, an immunoregulatory B cell subset, in mitigating acute lung injury (ALI) and acute respiratory distress...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Texas Health Science Center at Houston a $1.39 million Project Grant (CFDA 93.837: Cardiovascular Diseases Research) beginning September 1, 2025, and concluding May 31, 2029, to investigate ribosome dysfunction mechanisms in systemic sclerosis–related interstitial lung disease (SSC-ILD). The research will identify how enhanced ribosome biogenesis (RIBI) drives an altered...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $1.41 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for May 31, 2029. The award funds research to characterize lung interstitial neutrophils (LINs)—a specialized immune cell subset with enhanced bactericidal capacity. The project investigates the origin,...
- Federal Project Grant Award Summary Baylor College of Medicine received a $752,618 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 2, 2025, through May 31, 2030. The grant supports research investigating the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery occurring in 10-50% of patients. The research utilizes a...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $156,168 to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center for research exploring the role of the Hedgehog pathway-primary cilia axis in human lung alveolarization and disease under the Cardiovascular Diseases Research program (CFDA 93.837). The two-year project, initiated August 1, 2025 and concluding July 31, 2027, investigates how hedgehog signaling regulates alveolar...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $873,801 to Icahn School of Medicine at Mount Sinai, effective June 1, 2026, through February 28, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds basic and translational research investigating epithelial reprogramming mechanisms that distinguish normal (euplastic) versus abnormal (dysplastic) lung repair processes. The research aims to...
- Federal Grant Award Summary Baylor College of Medicine received a $1.58 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of May 31, 2030. The award funds research investigating the detrimental effects of the B-cell-Th17 (T helper 17) axis on antiviral immunity in smokers. The research team will conduct mechanistic studies to determine how cigarette...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $107,752 Project Grant awarded September 12, 2025, by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports a research initiative titled "Epithelial Cell Mediated Fibroblast Activation Through CTHRC1-TGFB Signaling in Fibrotic Lung Diseases," with a completion date of August 31, 2027. The research...
Baylor College of Medicine received a $1.60M project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with completion scheduled for April 30, 2028. The grant funds basic research investigating the role of the let-7 microRNA/EZH2/BACH1 double negative feedback loop in alveolar cell-induced interstitial lung disease (ILD). The research addresses a critical knowledge gap in understanding how impaired alveolar repair and regeneration mechanisms contribute to idiopathic pulmonary fibrosis and other severe lung diseases. The project delivers mechanistic research outputs across three specific aims: elucidating the let-7/EZH2/BACH1 axis role in maintaining alveolar type 1 (AT1) cell homeostasis during lung injury; investigating the feedback circuit's contribution to fibrotic remodeling in AT2 and AT1 cells; and examining conservation and function of this regulatory axis in human AT2-to-AT1 cell differentiation. Research activities will employ molecular and cellular studies to identify potential therapeutic targets for preventing excessive extracellular matrix deposition and fibrotic scarring in interstitial lung diseases, directly supporting NHLBI's mission to advance prevention and treatment of lung and respiratory diseases through hypothesis-driven basic science research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 7/7/26 |