This $854,000 project grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to assess and characterize post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The grant recipient, The Johns Hopkins University, will utilize novel positron emission tomography (PET) imaging techniques to longitudinally profile lesional characteristics in animal...
This federal Project Grant award of $897,448 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a study titled "Causality of Post-TB Lung Disease: Population-Level Evidence from Rural Uganda." The study aims to evaluate lung function and respiratory symptoms both before and after people develop tuberculosis (TB) in order to better understand the relationship between TB, underlying risk factors like smoking,...
The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, awarded a $536,148 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Tufts College, doing business as Tufts University School of Medicine, to conduct research on integrating point-of-care urine isoniazid testing into routine tuberculosis (TB) care in India. The central goal is to enable early and accurate identification...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $817,252 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Vanderbilt University Medical Center (VUMC) to conduct a study entitled "Investigating Multiple PK and PD Relationships for TB-HIV (IMPPROVE TB-HIV)". This 1-year project aims to leverage VUMC's Tuberculosis Sentinel Research Network to perform pharmacokinetic-pharmacodynamic (PK-PD) analyses on first-line...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,089,360 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Rutgers, The State University of New Jersey. The 5-year grant, which began on September 10, 2025, will establish a consortium of experienced investigators and a global network of clinical research sites to support the evaluation of early-stage tuberculosis (TB) diagnostic tests. The program aims to accelerate the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $209,408 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Pittsburgh. The 5-year grant, starting on September 19, 2025, supports research to characterize the frequency and functionality of unconventional T cell populations, such as CD1-restricted, MR1-restricted, and γδ T cells, in early lung granulomas during tuberculosis (TB) infection in a non-human primate...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $743,817 Project Grant to the Oregon Health & Science University (OHSU). The funding, awarded on August 12, 2025, will support research to define T cell receptor (TCR) families associated with protection from progression to pulmonary tuberculosis (TB) disease, particularly in the context of HIV co-infection. The study aims to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $742,499 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Alabama at Birmingham (UAB). The grant supports research focused on investigating siderophore secretion and drug efflux mechanisms in Mycobacterium tuberculosis. Key objectives include shedding light on the unique secretion system in M. tuberculosis and revealing the molecular mechanisms driving...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,173,748 project grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Emory University. The grant supports research to understand infectiousness and social mixing patterns during asymptomatic tuberculosis (TB), which may drive population-level transmission. The project aims to address critical knowledge gaps on where, when, and by whom TB transmission is occurring, particularly outside of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $813,450 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Case Western Reserve University. The 5-year grant, effective August 1, 2025, supports research to evaluate human T cell responses to Mycobacterium tuberculosis antigens that are processed and presented by infected macrophages. The goal is to develop a better understanding of how variation in human T cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,136,143 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Trustees of Indiana University, doing business as Indiana University Indianapolis. The grant, awarded on Aug 22, 2025, supports a research project to investigate the prevalence, risk factors, and impact on quality of life of post-tuberculosis lung disease (PTLD) in youth aged 15-24 with and without HIV across 6 African countries. The project will leverage the Tuberculosis Sentinel Research Network to enroll 600 youth with and without tuberculosis, conduct enhanced data collection on lung health, air pollution, and well-being, and implement youth-friendly supports to understand the burden of PTLD in this vulnerable population. The findings are expected to inform the development of tailored interventions and care models to promote long-term lung health for youth affected by tuberculosis.