Project Grant R01HL179758
- The federal Project Grant award of $1,148,652 was made on April 1, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports research and development of an ultra-high spatial resolution photon-counting computed tomography (CT) system with multiple focal spots. The key products to be delivered include: Developing system models and...
- This $726,205 federal Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and validation of a new super-resolution intravascular ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the coronary vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques to better assess plaque vulnerability and prevent acute coronary syndromes. The project involves creating an...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), is for the "Development of Integrated OCT/US/PAT System for Intravascular Imaging". The $617,366 award is being used to develop a multimodal intravascular imaging system incorporating optical coherence tomography (OCT), ultrasound (US), and photoacoustic tomography (PAT) technologies. The objectives are to design and construct a confocal...
- This federal Project Grant award of $158,910.00, made by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research by Dr. Qing Hao at Duke University to investigate the proteomic profile of intracranial atherosclerotic disease (ICAD) in order to identify novel biomarkers associated with ICAD occurrence and ICAD plaque activity. The research project aims to discover proteins and pathophysiological mechanisms specific to ICAD...
- The University of Cincinnati, through its Sponsored Research Services Division, was awarded a $156,276 project grant by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on "Hematopoietic Cells and Chemokine Regulation in Abdominal Aortic Aneurysm Associated Thrombosis". The project, with a performance period from August 1, 2025 to June 30, 2027, aims to investigate the role of platelet activation and...
- This federal Project Grant award of $747,281 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a real-time, non-invasive technique to characterize the mechanical properties of blood clots (thrombi) as they age. The project aims to utilize ultrasound-responsive nanodroplets that can transition into microbubbles when exposed to focused ultrasound, a process known as acoustic droplet vaporization (ADV). By leveraging ADV, the...
- This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $2,896,024.00 to Duke University to develop a Virtual Preclinical CT (VPCT) Platform for advanced imaging and theranostics in head and neck cancer research. The project aims to integrate high-resolution photon-counting CT (PCCT) imaging with sophisticated computational models to simulate tumor behavior, optimize imaging protocols, and evaluate therapeutic interventions...
- This federal Project Grant award, with a total funding amount of $304,415.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The goal of this 1-year project is to develop a software solution that uses artificial intelligence and image analytics to improve cardiovascular risk prediction from screening CT calcium score (CTCS) images. The project team, which includes engineers and clinicians from...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a $771,485 research project titled "CAROTID-MAP CAROTID ATHEROSCLEROTIC RISK ASSESSMENT THROUGH IMAGING ANDPREDICTION". The project aims to develop reliable imaging-derived markers in carotid artery computed tomography angiography (CTA) scans to identify high-risk plaque features associated with cryptogenic stroke. The research...
- This $169,560 Project Grant was awarded on March 1, 2025 by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the Regents of the University of Michigan. The grant supports research to elucidate the role of the PERK/EIF2A/ATF4 endoplasmic reticulum stress response and MLL1-mediated CHOP expression in vascular smooth muscle cell apoptosis, with the goal of identifying therapeutic targets to limit abdominal aortic aneurysm (AAA) expansion. The research...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) for $776,129 aims to leverage recent advances in photon counting CT (PCCT) imaging to enhance understanding and treatment of unruptured intracranial aneurysms (UIAs) in mouse models. The key products and services to be delivered under this 4-year grant include: Establishing optimized PCCT protocols for high-resolution, detailed visualization of cerebral arteries and aneurysm morphology in mouse brains, by optimizing parameters such as X-ray dose, detector settings, and image reconstruction algorithms. Validating the PCCT imaging findings against histological analysis to confirm the reliability of PCCT as a non-invasive alternative for monitoring UIA growth. Conducting longitudinal PCCT studies to assess the efficacy of aspirin in slowing UIA growth and maintaining vessel wall integrity in male and female animal models, providing insights into sex-specific vulnerabilities and differential treatment effects. The grant was awarded to Duke University's Office of Research Administration, a leading institution renowned for its extensive research capabilities across multiple scientific disciplines, including medical research, technology development, and clinical trials.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $776.1k | 8/25/25 |