Project Grant R01HL180433
- The federal Project Grant award by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $534,761 to the University of California, Los Angeles (UCLA) to develop "Magnetoelastic Vascular Grafts" (MVGs). The MVGs are a transformative platform technology that can wirelessly and continuously monitor blood flow and detect stenosis (narrowing) in vascular grafts, a common issue affecting nearly 40% of grafts within 2 years of implantation. The...
- The federal Project Grant award, titled "Focal Myocardial Delivery of Small Molecule Nitroalkenes Using Ultrasound Targeted Microbubble Cavitation to Improve Ventricular Recovery Following Myocardial Infarction," was awarded by the National Heart Lung and Blood Institute under CFDA 93.837, the Cardiovascular Diseases Research program. The $720,676 award, with a start date of March 4, 2025 and an ultimate completion date of December 31, 2028, aims to develop a novel therapeutic strategy...
- This $410,956 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Michigan Technological University supports research to stratify thrombosis risk in Kawasaki disease patients using computational fluid dynamics (CFD) analysis of coronary artery aneurysms (CAA) and ectasia (CAE). The research aims to complement current clinical assessment based on the z-score metric with additional hemodynamic indices like flow velocity, wall...
- This $726,205 federal Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and validation of a new super-resolution intravascular ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the coronary vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques to better assess plaque vulnerability and prevent acute coronary syndromes. The project involves creating an...
- This federal Project Grant award of $110,635.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to characterize how red blood cell aggregation and membrane deformability affect endothelial cell injury and microvascular thrombosis in sepsis patients. The project will use microfluidics assays to analyze patient blood samples and apply machine learning to determine the impact of rheology on clinical outcomes. The research will also assess the...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), is for the "Development of Integrated OCT/US/PAT System for Intravascular Imaging". The $617,366 award is being used to develop a multimodal intravascular imaging system incorporating optical coherence tomography (OCT), ultrasound (US), and photoacoustic tomography (PAT) technologies. The objectives are to design and construct a confocal...
- This $165,980 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports a computational analysis of hemodynamics in patients with renal artery fibromuscular dysplasia (FMD). The goal is to investigate the impact of large vessel and small vessel disease on FMD versus atherosclerotic renal artery stenosis (ARAS) patients through hemodynamic indices like fractional flow reserve (FFR) and index of microvascular resistance...
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop an efficient, contrast-free, 3D whole-lung low-field magnetic resonance imaging (MRI) protocol for the detection of pulmonary embolism (PE). The project, awarded to the Regents of the University of Michigan, will leverage advancements in low-field MRI hardware and deep learning techniques to create a rapid, comfortable, and radiation-free...
- This Project Grant award, titled "DEVELOPING IMPLEMENTATION SCIENCE EXPERTISE IN CARDIOVASCULAR HEALTH SERVICES RESEARCH", is funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $133,085 grant, awarded on September 1, 2025, supports research activities at the University of Michigan to improve the management of anticoagulant medication and increase the use of evidence-based outpatient treatment for low-risk...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
This federal Project Grant award of $747,281 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a real-time, non-invasive technique to characterize the mechanical properties of blood clots (thrombi) as they age. The project aims to utilize ultrasound-responsive nanodroplets that can transition into microbubbles when exposed to focused ultrasound, a process known as acoustic droplet vaporization (ADV). By leveraging ADV, the researchers at the University of Michigan seek to establish a micro-rheology methodology that can spatiotemporally quantify the evolving mechanical characteristics of aging thrombi, such as elastic modulus. This innovative approach could provide critical insights into thrombus development stages and guide tailored treatment strategies to improve patient outcomes for cardiovascular conditions associated with thrombosis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $747.3k | 9/18/25 |