Project Grant R01HL179686
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) in the amount of $772,400.00 supports research on developing decellularized cartilage and progenitor cells for laryngotracheal reconstruction. The project aims to address the high failure rate and restenosis issues associated with current laryngotracheal reconstruction procedures in children with severe subglottic stenosis, a narrowing of the airway below the vocal...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support research to establish new tools and protocols for optimizing the design of airway stents used to treat tracheobronchomalacia, a rare disease involving airway collapse. The $445,000 award to The Children's Hospital Corporation, doing business as Boston Children's...
- This federal Project Grant award from the National Heart Lung and Blood Institute under CFDA Program 93.837 - Cardiovascular Diseases Research provides $306,872 to Airalux Medical, Inc. to develop a digital incentive spirometry device. The goal is to improve patient adherence and clinical workflows for preventing post-surgical lung complications, which occur in 1 in 20 patients undergoing an overnight hospital stay. The device uses sensors and software to automatically track patient usage and...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding the development of a nanofiber patch for the treatment of pediatric tracheal stenosis, a life-threatening condition involving airway narrowing. The $154,000 award to Colorado State University aims to create a synthetic trachea patch that can maintain airway patency and regenerate cartilage-like...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $422,075 to The University of Iowa to develop an electromagnetic-actuated, dynamic cell culture method for airway epithelial cells. The project aims to prototype a novel "Magniwell-12" system that integrates a porous PDMS membrane, membrane holder, magnetic actuator, and peripheral heat dissipation/control circuits. This will enable dynamic stretch-relax...
- The National Heart, Lung, and Blood Institute, through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded Smartairway LLC a $313,365 project grant on August 1, 2025 to develop a novel articulating stylet device for improving first-pass endotracheal intubation success rates. The proposed SmartStylet device can flex the endotracheal tube 60 degrees anteriorly and 15 degrees posteriorly while in the patient's airway, allowing real-time adjustments to match the...
- The National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $305,218 Project Grant to Respair, Inc. for the development of ASSURANCEET, a novel endotracheal tube with a micro-baffle sealing mechanism to protect pediatric patients from airway trauma and collapse. The goal of the project is to assess the feasibility and safety of the ASSURANCEET device for use in pediatric airways, as the current endotracheal tube designs...
- This $321,679 Project Grant, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development and testing of an expandable pediatric pulmonary heart valve device. The research aims to create a valve that can grow larger with the patient to address the challenge of multiple open-heart surgeries required for infants and children with severe heart valve defects. The key research activities include optimizing the...
- This $721,826 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify molecular mechanisms regulating alveolar matrix fibroblast function and their role in supporting vascular capillary formation. The research is being conducted by Children's Hospital Medical Center in Cincinnati, Ohio to advance the understanding of alveolar septation and septal wall maturation, which is...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $180,174 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia Research Institute. The grant will fund a study to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. Key objectives include: 1) Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric...
This federal Project Grant award, provided by the National Heart Lung and Blood Institute under CFDA program 93.837 Cardiovascular Diseases Research, aims to develop new flexible 3D-printed airway splint designs and computational models to predict airway growth and device damage for the treatment of tracheobronchomalacia in children. The $709,172 award to Georgia Tech Research Corporation will fund pre-clinical and clinical studies over a 5-year period from September 2025 to June 2030. The key products and services to be delivered include new auxetic airway splint designs that allow for radial and longitudinal airway growth, computational models to simulate airway growth and device degradation, and continued patient treatment under an FDA expanded access program. The research seeks to address limitations of previous airway splint designs that restricted airway growth and posed a risk of fracture.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $709.2k | 8/22/25 |