This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $772,400.00 to The Children's Hospital of Philadelphia (CHOP) to develop decellularized cartilage and progenitor cells for improved laryngotracheal reconstruction (LTR) procedures. The project aims to address the high failure rate and restenosis issues associated with current autologous cartilage grafts used in pediatric LTR surgeries to treat severe subglottic stenosis, a narrowing of the airway below the vocal folds. By engineering alternative graft materials and progenitor cell therapies, the research seeks to enhance the efficacy and durability of LTR interventions for this pediatric patient population. The award has a period of performance from February 1, 2025 to November 30, 2027.
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