This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding the development of a nanofiber patch for the treatment of pediatric tracheal stenosis, a life-threatening condition involving airway narrowing. The $154,000 award to Colorado State University aims to create a synthetic trachea patch that can maintain airway patency and regenerate cartilage-like...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $772,400.00 to The Children's Hospital of Philadelphia to develop decellularized cartilage and progenitor cells for laryngotracheal reconstruction. The project aims to address severe subglottic stenosis, a narrowing of the airway below the vocal folds that commonly develops in premature infants following intubation. The research seeks to engineer functional...
This Project Grant award of $466,500, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Washington, aims to develop a novel diagnostic pipeline leveraging computer vision and computational fluid dynamics to accurately quantify stenosis morphology and respiratory effort in pediatric subglottic stenosis (SGS) patients. The pipeline will reconstruct 3D airway anatomy from standard endoscopy and compute airflow parameters,...
This federal Project Grant award of $313,365.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop and test a novel articulating stylet device called the SmartStylet. The device is designed to improve first-pass success rates for endotracheal intubation, a critical medical procedure, by allowing real-time adjustment of the stylet's curvature to match the patient's airway anatomy. The proposed work under this...
The Project Grant award R01HD116968, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting the "MODEL-DIRECTED DESIGN OF VAGINAL STENTS TO PREVENT POST-RADIATION STENOSIS". The $598,983 award, made on December 16, 2024, aims to develop a self-fitting vaginal stent utilizing shape-memory polymer foam technology to address the...
This Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a modern Electrical Impedance Tomography (EIT) device for monitoring children in the Intensive Care Unit (ICU). The $299,900 award to Goodlife Inventors LLC will fund efforts to (1) generate initial designs for an advanced lightweight EIT belt and (2) assess the technical feasibility of a miniaturized, easier to use EIT core device. If...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $656,750 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to advance the use of Electrical Impedance Tomography (EIT) for bedside lung perfusion imaging in patients with Acute Respiratory Distress Syndrome (ARDS). The key...
This $203,974 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a research project to investigate the effects of normal and diseased extracellular matrix (ECM) on the self-renewal and differentiation of airway basal epithelial cells. The project leverages novel tools developed by the co-PIs, including "inside-out" airway organoids and ECM hydrogels derived from normal and...
This federal Project Grant award for $220,000, provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), aims to deliver a comprehensive mathematical and computational framework for optimizing the design of next-generation stents. Key products and services to be provided under this 3-year award (August 1, 2024 to July 31, 2027) include: Developing a reduced model optimization module for the optimal...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $500,000 in funding to Starlight Cardiovascular, Inc., a for-profit medical device company headquartered in San Diego, California. The grant supports the development and commercialization of a ductus arteriosus stent system designed to address critical blood vessel patency issues in newborns with certain congenital heart defects. The...