Project Grant R01HL178516
- Federal Grant Award Summary The University of Michigan received a $357,191 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 7, 2025, with completion by July 31, 2030. This research initiative investigates seizure-induced remodeling of cholinergic networks in Dravet syndrome, a severe developmental and epileptic...
- Federal Grant Award Summary Michigan Technological University received a $589,998 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award supports research investigating cardiac sensory and sympathetic nerve dysregulation in hypertrophic cardiomyopathy (HCM), a genetic heart disease affecting approximately 1 in 500 individuals and representing the...
- Federal Project Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $651,349 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of May 31, 2029. This award funds research investigating stoichiometric, adhesion, and contractile deficits in desmoplakin cardiomyopathy, a condition caused by genetic...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a Project Grant totaling $385,091 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853). This five-year award, with a completion date of July 31, 2030, funds research to develop a closed-loop therapeutic intervention to prevent Sudden Unexpected Death in Epilepsy (SUDEP). The...
- Federal Grant Award Summary The University of Michigan received a $619,882 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective July 5, 2025, with completion targeted for April 30, 2030. The grant funds a mechanistic clinical trial designed to personalize heart failure treatment through genomic analysis. The research will prospectively validate a polygenic risk score (PRS) for predicting...
- Federal Grant Award Summary The University of Michigan received a $191,629 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 15, 2026, with completion targeted for April 30, 2031. This research initiative addresses venous thromboembolism (VTE) prevention and management in pregnant and postpartum patients with sickle cell disease (SCD), a medically vulnerable population experiencing maternal...
- Federal Project Grant Award Summary Vanderbilt University received a $147,486 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded September 30, 2025, with completion targeted for May 31, 2027. The award funds research investigating the neural mechanisms underlying cardiorespiratory dysfunction in temporal lobe epilepsy (TLE) and its relationship...
- Federal Grant Award Summary The University of Michigan received a $1,494,562 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 20, 2025, with a completion date of June 30, 2030. The research initiative will develop an in situ micro-rheology technique utilizing ultrasound-responsive nanodroplets to characterize aging thrombi (blood clots) in real-time and non-invasively. The primary...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Michigan a Project Grant totaling $256,785 under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a preliminary metabolomics-genome-wide association study (GWAS) investigating the relationship between genetic variants and sepsis severity. Awarded on September 15, 2025, with a completion date of August 31, 2027, this research leverages biospecimens from the...
- Federal Project Grant Award Summary The University of Michigan received a $304,007 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 18, 2025, with completion targeted for December 31, 2027. The project, "Leveraging a 'Sliding-Window' Type I CRISPR Base Editing Platform to Correct CFTR Null Mutations," delivers research and development services focused on advancing a novel gene-editing...
The University of Michigan received a $765,515 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded May 1, 2026, with completion targeted for March 31, 2030. This research initiative investigates neuro-cardiac mechanisms underlying Sudden Unexpected Death in Epilepsy (SUDEP), specifically examining how loss-of-function variants in the SCN1A gene contribute to cardiac arrhythmias and respiratory dysfunction in Dravet Syndrome, a severe developmental and epileptic encephalopathy. The primary deliverable is translational research utilizing a transgenic rabbit model of SCN1A haploinsufficiency to test hypotheses regarding how SCN1A deficiency increases SUDEP risk through cardiac and respiratory pathophysiology mechanisms. The research outputs will advance understanding of channelopathy-linked genetic epilepsy mechanisms by bridging the limitations of existing mouse and induced pluripotent stem cell models through a complete organism system that more closely replicates human cardiac and respiratory physiology. Findings from this project are intended to identify potential therapeutic targets and inform clinical interventions to reduce SUDEP mortality in patients with Dravet Syndrome and related genetic epilepsies, thereby contributing to the NHLBI's mission to reduce morbidity and mortality from cardiovascular and related disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $765.5k | 5/5/26 |