Project Grant R21HL181071
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is providing $174,960 to the Regents of the University of Michigan to develop and evaluate a personalized approach to initial fluid resuscitation for patients with hospital-onset sepsis. The key products and services to be delivered under this award include: 1) an electronic health record-based cohort study to understand the impact of initial fluid volume on outcomes in...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance precision medicine for Acute Respiratory Distress Syndrome (ARDS) and sepsis. The $2,295,984 award to the University of California, San Francisco (UCSF) will fund research to address critical unanswered questions about the distinct molecular phenotypes of ARDS and sepsis, and how to optimize real-time phenotyping and integrate analyses of phenotype-specific...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,061,189 to the Regents of the University of Michigan to conduct research on immune crosstalk in lung injury and fibrosis. The key objectives are to study epithelial cell regulation of fibrosis and its interaction with myeloid cells, uncover mechanisms for impaired innate immunity against gram-positive infections in fibrosis, test delivery of targeted therapeutics...
- This Project Grant award of $750,561 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund the SMART-SEPSIS study. The study aims to use electronic health record data and artificial intelligence/machine learning to model individual patient response to sepsis treatment and promote early but reasoned application of the hour-1 sepsis treatment bundle for patients with suspected community-onset lung sepsis. The goal is...
- This Project Grant, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), provides $196,245 to the Regents of the University of Michigan to develop and validate a multi-dimensional proteomic signature to predict treatment failure in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). The 4.5-year project aims to determine FVC trajectory and cumulative incidence of treatment failure across CTD-ILD subtypes,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $690,626 to the Regents of the University of Michigan to conduct research on the role of type I interferon signaling in modulating acute lung injury and regeneration of the alveolar epithelium. The key objectives are to: 1) identify the molecular effectors linking interferon signaling to cell cycle arrest in respiratory epithelial cells, 2)...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $721,728 to the Regents of the University of Michigan to conduct research on "Modulation of Pediatric Sepsis by Virus Persistence." The research aims to identify novel biomarkers that can help define sepsis phenotypes and predict patient responses to immunomodulatory therapies. Specifically, the study will investigate how persistent...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Temple University provides $683,299 to conduct research on the functional immune phenotypes of sepsis patients. The project aims to integrate microphysiological assays, omics data, and in silico modeling to better understand how different neutrophil subpopulations and their interactions with the vascular endothelium contribute to sepsis-induced organ dysfunction....
- This $1,380,474 federal Project Grant awarded on September 24, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to improve the care of patients with acute heart and lung diseases. The University of Michigan will develop data-driven models to support improved decision-making for intensive care unit (ICU) triage and inpatient bed assignment. The project will identify determinants of triage and bed assignment, develop a clinical decision...
- The National Heart Lung and Blood Institute, under its Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $412,250 project grant to Arizona State University (ASU) to develop a real-time, automated smart catheter analyzer for early identification of sepsis through continuous monitoring of urine biomarkers. This non-invasive approach aims to enable rapid sepsis diagnosis, within 200 minutes, to support quick clinical intervention and preservation of heart and lung...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will provide $256,785 to the Regents of the University of Michigan to conduct a preliminary metabolomics-genome-wide association study (GWAS) on sepsis-induced organ dysfunction and mortality. The study will leverage stored plasma and DNA specimens from the Crystalloid Liberal or Vasopressor Early Resuscitation in Sepsis (CLOVERS) trial to identify genomic and patient-level factors that contribute to acetylcarnitine blood levels in sepsis patients. The goal is to further understand the associations between genetic variants and sepsis metabolite levels in order to gain insights into mechanisms that enhance or attenuate sepsis severity and mortality. This award has a start date of Sep 15, 2025 and an ultimate completion date of Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $256.8k | 9/9/25 |