Project Grant R01HL172887

Award Date 1/15/25
Completion Date 11/30/28
Dollars Obligated $1.6M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
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This Project Grant award of $1,602,792 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a study on the "Phenotypic Consequences of Lipoprotein(a) in Diverse Populations." The study aims to address gaps in understanding the effects of lipoprotein(a), a causal cardiovascular disease risk factor, across diverse populations. The key research activities include:

  1. Assembling a large, ancestrally diverse consortium with validated lipoprotein(a) measures and genetic data to facilitate causal inference studies.
  2. Leveraging the diverse consortium to develop highly accurate lipoprotein(a) polygenic risk scores that can be used in studies without direct lipoprotein(a) measures.
  3. Conducting a suite of causal inference studies to identify both anticipated and unanticipated effects of lipoprotein(a) across broad phenotypic classes in diverse populations.

This research is expected to provide an essential foundation for future efforts to maximize the benefits and minimize the risks of therapeutic lipoprotein(a) lowering interventions. The award period is from January 15, 2025 to November 30, 2028.

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