Project Grant R01HL176017

Award Date 7/15/24
Completion Date 5/31/28
Dollars Obligated $2.2M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06519, USA
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Key activities include:

  • Characterizing lymphatic drainage and glymphatic transport concurrently in a hypertensive rat model (SHRSP) and normotensive controls (WKY)
  • Evaluating the impact of antihypertensive treatment on restoring lymphatic system function in the SHRSP rat model
  • Conducting gain-of-function and loss-of-function experiments to assess the contribution of lymphatic drainage defects to the development of CSVD
  • Performing comprehensive "omic" analysis of cerebrospinal fluid to identify molecular and biochemical changes associated with chronic hypertension

A sub-award of $80,005.297 was provided to Weill Medical College of Cornell University to conduct proteomic analysis of lymphatic collectors and cervical lymph nodes in the rat models.

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