The federal Project Grant award of $671,234 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of basolateral brain endothelial cilia in promoting vascular stability. The key products and services to be delivered under this grant include: Evaluating the localization and role of platelet-derived growth factor-BB (PDGF-BB) in the context of the extracellular matrix and basolateral...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $587,042 to the University of Missouri System to conduct research on the regulation of lymphatic muscle cell function by store-operated calcium entry signaling. The key objectives of the 5-year project are to: 1) assess the role of store-operated calcium entry (SOCE) in regulating lymphatic muscle cell calcium dynamics,...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $116,278 to the University of South Florida to investigate the plasminogen activator pathway and its role in the development of lymphatic malformations. The research aims to 1) assess the expression of key plasminogen activator enzymes and their activation of matrix metalloproteinases, and 2) attempt to rescue lymphatic valve...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $144,362 to Georgia Tech Research Corporation to conduct a multi-year research project focused on investigating the effectiveness and mechanisms of lymphaticovenous anastomoses (LVA) for treating lymphedema. The research aims to gain deeper insights into the biomechanics and adaptations of the lymphatic system in response to...
This $784,206 federal Project Grant award issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the role of the CSF-1/CSF-1R axis in myocardial infarction (MI) repair and remodeling. The research aims to examine the in vivo effects of macrophage-specific CSF-1R activation, investigate the role of fibroblast-derived CSF-1, evaluate the therapeutic potential of early CSF-1/CSF-1R axis activation, and...
This federal Project Grant award of $762,405.80 from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the cellular and molecular mechanisms by which cell-free hemoglobin (CFH) and oxidized low-density lipoprotein (oxLDL) contribute to microvascular hyperpermeability and lung injury during sepsis. The research will focus on understanding how CFH-induced oxidation of LDL leads to the activation of the...
This $2,087,677 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research focused on understanding how the chromatin remodeling factor CHD7 regulates the development of cardiac and craniofacial lymphatic vessels. The project aims to use confocal and live imaging, lineage tracing, single-cell multi-omic analysis, spatial transcriptomics, and CUT&RUN to determine the molecular mechanisms...
This federal Project Grant award for $125,431.00 was provided by the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), to the Sloan-Kettering Institute for Cancer Research in New York, NY. The award supports research to mechanistically dissect the WNK1-dependent pathway initiated by macrophage colony-stimulating factor (M-CSF)-induced macropinocytosis and investigate how this pathway is shifted during emergency granulopoiesis in...
This Federal Project Grant award in the amount of $815,229 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The primary objective is to use proteomics and genomics to identify biological pathways responsible for the development of cardiac dysfunction, the impact of social determinants of health (SDOH) on heart failure and atrial fibrillation risk, and the biological resilience to these conditions among Black...
This federal Project Grant award, totaling $508,436, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The funding supports research at the University of Texas Southwestern Medical Center to investigate the "two-hit" model for lymphatic malformations, a type of rare vascular disease. The key objectives are to examine the role of the KRAS oncogene and VEGF-C growth factor in the development of...