This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to elucidate the role of the mechanosensitive ion channel Piezo1 in lymphatic valve formation. The $808,121 award, valid from May 15, 2025 to February 28, 2029, will fund research at the University of Southern California to investigate how Piezo1 senses fluid flow and activates the transcription factor Prox1 to orchestrate lymphatic...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to investigate the effectiveness and mechanisms of lymphaticovenous anastomoses (LVA) for treating lymphedema. The $144,362 award to Georgia Tech Research Corporation will utilize computational modeling, in vivo experiments, and analysis of clinical LVA data to gain deeper insights into lymphatic flow regulation and...
This federal Project Grant award, totaling $2,218,392.00, was issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award supports a comprehensive research project aimed at investigating the role of lymphatic system dysfunction in the pathogenesis of cerebral small vessel disease (CSVD) in the context of chronic hypertension. Key objectives of the project include: 1) determining the impact of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, provides $116,278 to the University of South Florida to investigate the role of the plasminogen activator (PA) pathway in regulating lymphatic valve defects associated with lymphatic malformations. The researchers will assess the expression of key PA enzymes and utilize in vitro zymography to evaluate matrix metalloproteinase (MMP) activation,...
This federal Project Grant award R01HL172809, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a research project focused on understanding the role of vascular smooth muscle cells (VSMCs) and the lymphatic network in the development of atherosclerosis. The $559,893 award, which runs from January 6, 2025 to November 30, 2029, will fund three main research aims: Determining the functional role of VSMC-derived R-spondin 2 (RSPO2)...
This $333,567 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will fund a collaborative research effort at Saint Louis University to determine the role of lipids in regulating lymphatic permeability. The project aims to develop an integrated computational and experimental approach to understand how lipids and the CD36 translocase regulate lymphatic vessel integrity and cell signaling. Researchers will use a systems biology methodology...
This Project Grant award in the amount of $508,436 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to investigate the "two-hit" model for the development of lymphatic malformations, a rare and complex disease with variable clinical manifestations. The research aims to determine whether VEGF-C, a lymphangiogenic growth factor, renders lymphatic vessels sensitive to the...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, aims to investigate the cellular and molecular mechanisms underlying microvascular hyperpermeability and lung injury during sepsis. The research will focus on understanding how cell-free hemoglobin (CFH) released during sepsis can induce oxidation of low-density lipoprotein (OxLDL), leading to activation of the lectin-like OxLDL receptor 1 (LOX-1)...
This Project Grant award, with a total funding amount of $265,151.00, was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the University of Southern California. The project aims to use mathematical modeling and experiments to understand what regulates leakiness in the lymphatic system, with the goal of developing strategies to modulate lymphatic permeability. The research will investigate how lipids regulate CD36, a long-chain fatty acid translocase,...
This $408,599 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of the TGF-beta/SMAD3 pathway in endothelial damage and cardiac remodeling caused by doxorubicin chemotherapy. The research aims to assess how doxorubicin-induced endothelial reprogramming via this pathway contributes to the development of cardiomyopathy, and whether suppressing SMAD3...