The University of Texas Southwestern Medical Center was awarded a $815,229 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) on January 1, 2025. The objective of this 4-year grant is to use proteomics and genomics to identify biological pathways responsible for the development of heart failure and atrial fibrillation, and to examine how social determinants of health and resilience influence cardiovascular disease risk in Black Americans.
The project will leverage data from the Jackson Heart Study to: 1) define proteins and protein networks associated with clinical and subclinical cardiac dysfunction; 2) identify proteins and pathways linked to atrial fibrillation and subclinical arrhythmia; and 3) elucidate molecular mechanisms connecting social determinants of health, and resilience to adversity, to cardiac function and arrhythmia. The University of Washington is a sub-grantee on this project, responsible for analyzing proteomic data related to atrial fibrillation, conducting genomic analyses, and leading manuscript preparation.
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