The National Heart, Lung, and Blood Institute (NHLBI) awarded a $125,431.00 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to the Sloan-Kettering Institute for Cancer Research, a non-profit organization in New York. The grant, titled "WNK1-DEPENDENT MACROPINOCYTOSIS MEDIATES EMERGENCY MYELOPOIESIS", supports research to mechanistically dissect the WNK1-dependent pathway initiated by macrophage-colony stimulating factor-induced macropinocytosis, and to investigate how this pathway is shifted during emergency granulopoiesis. The research aims to advance understanding of the cellular machinery necessary to rapidly increase granulocyte output during infection and systemic inflammation. The project will also explore targeting the WNK1 pathway as a potential therapeutic approach for sepsis. The award period is from Sep 1, 2024 to Aug 31, 2026.