Project Grant R01HL175575
Award Date
9/1/24
Completion Date
5/31/28
Dollars Obligated
$729K
Federal Agency
National Heart Lung and Blood Institute
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,727,892 to support research on the role of the RASA1 gene in embryonic vascular and lymphatic development. The award aims to define the cellular and molecular effects of RASA1 deficiency that contribute to lymphatic defects, investigate how RASA1 mediates vascular regression and its link...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $127,305 to support research at Boston Children's Hospital from January 2, 2025 to December 31, 2026. The grant will fund a study to "Unravel Immune Cell Interactions and Multicellular Dynamics in GNAQ-Driven Capillary Malformation", focusing on understanding the cellular mechanisms behind a rare vascular disorder...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $508,436 to The University of Texas Southwestern Medical Center to investigate the "two-hit" model for the development of complex lymphatic anomalies (CLAs). The research aims to 1) test whether vascular endothelial growth factor C (VEGF-C) in the microenvironment renders lymphatic vessels sensitive to the effects of...
This Project Grant award, identified as R01HL170118, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award, totaling $495,159.00, will fund research to investigate the role of the protein CARMIL1 in regulating endothelial cell barrier function and its potential impact on acute respiratory distress syndrome (ARDS). The study, to be conducted by the University of Illinois, will use...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $116,278 to the University of South Florida to investigate the role of the plasminogen activator (PA) pathway in lymphatic malformations. The key research activities include: Assessing the expression of key PA enzymes and utilizing in vitro zymography to evaluate matrix metalloproteinase (MMP) activation related to lymphatic valve defects...
This $658,885 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to advance the fundamental understanding of the molecular mechanisms governing the development of pulmonary arterial hypertension (PAH). The research will utilize a combination of pulmonary arterial endothelial cell cultures and animal PAH models to: Determine how the protein factor Response Gene to Complement 32 (RGC-32) regulates...
This $2,158,878 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to understand the role of the enzyme ALDH1A3 in endothelial cell dysfunction and intimal hyperplasia associated with vascular surgery. The grant aims to: 1) Resolve the endothelial cell-specific role of ALDH1A3 in impairing endothelial cell function and its regulation of the transcription factor KLF2 to advance understanding of the...
This $686,458 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a collaborative research effort between multiple institutions, led by Yale University, to develop a quantitative, predictive model of vascular remodeling in health and disease. The key products and services to be delivered through this grant include: Characterizing the roles of vascular endothelial...
This $1,568,003.00 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure control. The key aims of the grant are to: Determine if reduced endothelial progranulin levels facilitate the genesis and progression of hypertension via NOX1-derived reactive oxygen species, AMPK oxidation, and endothelial cell...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,332,404 to investigate the role of basolateral endothelial cilia in promoting vascular stability in the brain. The key research objectives are to: 1) evaluate the localization of platelet-derived growth factor-BB (PDGF-BB) in the context of the extracellular matrix and basolateral endothelial cilia, 2) investigate the role of...