This $729,165 project grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant supports research to study the biological consequences of RASA1 deficiency and identify synergistic genetic factors that promote the emergence of vascular malformations. The project aims to: 1) Identify partners that collaborate with RASA1 haploinsufficiency to drive vascular malformation development, and 2)...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to investigate the genetic and environmental factors contributing to the development of complex lymphatic anomalies (CLAs), a group of rare and debilitating vascular diseases. The $508,436 award to The University of Texas Southwestern Medical Center will test the hypothesis that CLAs require both a genetic mutation and a permissive lymphangiogenic...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $116,278 to the University of South Florida to investigate the role of the plasminogen activator (PA) pathway in lymphatic malformations. The key research activities include: Assessing the expression of key PA enzymes and utilizing in vitro zymography to evaluate matrix metalloproteinase (MMP) activation related to lymphatic valve defects...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The Children's Hospital Corporation (Boston Children's Hospital) provides $127,305 to support research focused on unraveling the immune cell interactions and multicellular dynamics involved in GNAQ-driven capillary malformations. The research aims to: 1) Determine the role of macrophage interaction in mosaic endothelium, and 2) Characterize the interaction among...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $466,125.00 to New York University School of Medicine to elucidate the role of mitochondrial function in rasopathies. The research aims to analyze mitochondrial morphology and function, including enzymatic activities and oxygen consumption, in tissues from a rasopathy mouse model. It will...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $112,034 to the Rector & Visitors of the University of Virginia (UVA) to support research on the mechanisms controlling arterial-venous specification during embryonic vascular development. The key objectives are to: Rigorously define the cell cycle state of arterial and venous endothelial cells in the developing embryo using FUCCI2...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is providing $865,694 to The Children's Hospital Corporation (Boston Children's Hospital) to investigate the role of the neuropilin-2 (NRP2) receptor in regulating lymphatic system function. The research aims to define how NRP2 signaling through different ligands can either promote or inhibit lymphatic fluid drainage and lipid absorption, with the...
The National Institute of Child Health and Human Development (NICHD) awarded a $493,409 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Oregon Health & Science University (OHSU) to investigate the role of the renin-angiotensin system (RAS) at the maternal-fetal interface. The key objectives are to determine the cell-specific contributions of the RAS protein ACE2 in the placenta and decidua, and to examine RAS gene expression, protein abundance, and...
The federal Project Grant award R03HD113887, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of the ZFHX4 gene in lung mesenchyme development and its potential implications for understanding the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia (CDH). The $164,990 award, with a performance period from August 1, 2024 to...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $291,848 to Tulane University to evaluate the impact of loss of heterozygosity on localized arteriovenous malformation (AVM) formation in hereditary hemorrhagic telangiectasia (HHT). The project aims to develop an HHT mouse model of SMAD4 loss of heterozygosity, compare it to previous SMAD4 knockout models, and explore the role of localized loss of function...