This $131,783 federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support research to identify blood and bronchoalveolar lavage fluid biomarkers for COPD phenotypes and acute exacerbations. The principal investigator, Dr. Craig Hersh at Brigham and Women's Hospital, will lead the development and implementation of a study protocol to collect biospecimens from COPD patients undergoing...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support research to identify functional genetic variants associated with chronic obstructive pulmonary disease (COPD) using deep learning models of alternative splicing in human airway epithelial cells. The total award amount is $2,377,618, with a project period from August 1, 2024 to May 31, 2028. The primary awardee,...
This Project Grant award, with a total funding amount of $626,247, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant aims to develop a tool that can leverage quantitative imaging data from lung cancer screening to identify individuals at risk for chronic obstructive pulmonary disease (COPD), which is the third leading cause of death globally. The key products and services to be delivered...
This $753,018.00 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify early life risk factors that contribute to airway-to-lung mismatch, known as dysanapsis, which is a major predictor of chronic obstructive pulmonary disease (COPD) risk. The project will leverage 8 longitudinal birth cohorts to examine the relationships between early life exposures, such as...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to optimize the effectiveness and implementation of COPD self-management treatment. The $725,088 award to Rush University Medical Center will fund a hybrid effectiveness-implementation study to identify the optimal combination of COPD self-management treatment components, including self-management education, physical...
This federal Project Grant award, with a total funding amount of $2,020,089, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to investigate the role of viral infections and autoantibodies in the progression of chronic obstructive pulmonary disease (COPD) and emphysema. Specifically, the research team will utilize advanced phage immunoprecipitation sequencing (PhIP-seq) technology to...
This is a Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837). The $708,063 award will fund a research project at the University of Virginia from May 1, 2025 to February 28, 2030 to study post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) develop methods to identify...
This Project Grant award of $116,625 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund a research study to characterize multi-volume airway and chest wall deformation in chronic obstructive pulmonary disease (COPD). The study will leverage established datasets from nationwide longitudinal lung studies to develop normative models of airway and chest wall deformation metrics, identify unique subtypes of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, aims to conduct a multi-omic characterization of chronic obstructive pulmonary disease (COPD) in females. The $572,076 award, granted to Pennsylvania State University's Milton S. Hershey Medical Center, will support research to better understand the genetic basis and molecular mechanisms underlying COPD in women, who are disproportionately...
This Project Grant award of $812,189.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to better understand pulmonary hypertension in chronic obstructive pulmonary disease (COPD) patients using advanced CT imaging techniques. The goal is to identify CT imaging features that can predict the presence and subtype of pulmonary hypertension in COPD, which will enable non-invasive screening and diagnosis....